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CG4239 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32606, updated on 9-Dec-2024

Summary

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Official Symbol
CG4239provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030745
Locus tag
Dmel_CG4239
See related
AllianceGenome:FB:FBgn0030745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4239
Summary
Predicted to enable potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in sarcoplasmic reticulum. Is expressed in adult head; adult heart; indirect flight muscle cell; larval muscle system; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38A (transmembrane protein 38A) and TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG4239 in Genome Data Viewer
Location:
14C2-14C2; 1-53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16385278..16388702)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16279311..16282735)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Furin 2 Neighboring gene uncharacterized protein Neighboring gene TH1 Neighboring gene meiotic 41 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T in Drosophila melanogaster Indirect Flight Muscles. Katti P, et al. G3 (Bethesda), 2017 Oct 5. PMID 28866639, Free PMC Article
  2. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
  3. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Asha H, et al. Genetics, 2003 Jan. PMID 12586708, Free PMC Article
  4. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article
  5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4239-PA
CG4239-PB
CG4239-PC
CG4239-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16385278..16388702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167515.2 → NP_727972.1  uncharacterized protein Dmel_CG4239, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXG9
    Related
    FBpp0074044
    Conserved Domains (1) summary
    pfam05197
    Location:42 → 226
    TRIC; TRIC channel

  2. NM_132894.3 → NP_573122.1  uncharacterized protein Dmel_CG4239, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573122.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXG9
    Related
    FBpp0074045
    Conserved Domains (1) summary
    pfam05197
    Location:42 → 226
    TRIC; TRIC channel

  3. NM_167516.2 → NP_727973.1  uncharacterized protein Dmel_CG4239, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727973.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXG9
    Related
    FBpp0074046
    Conserved Domains (1) summary
    pfam05197
    Location:42 → 226
    TRIC; TRIC channel

  4. NM_001298396.1 → NP_001285325.1  uncharacterized protein Dmel_CG4239, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285325.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXG9
    Conserved Domains (1) summary
    pfam05197
    Location:42 → 226
    TRIC; TRIC channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXG9 Q9VXG9

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