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5PtaseI Inositol polyphosphate-5-phosphatase type I [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326119, updated on 9-Dec-2024

Summary

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Official Symbol
5PtaseIprovided by FlyBase
Official Full Name
Inositol polyphosphate-5-phosphatase type Iprovided by FlyBase
Primary source
FLYBASE:FBgn0259178
Locus tag
Dmel_CG42283
See related
AllianceGenome:FB:FBgn0259178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5Ptasel; BcDNA:RE64196; CG31107; CG31110; CG42283; CG7613; dm5PtaseI; Dmel\CG42283; Inpp5a; IPP
Old locus tag
Dmel_CG31107; Dmel_CG31110
Summary
Enables inositol-polyphosphate 5-phosphatase activity. Involved in phosphatidylinositol metabolic process. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See 5PtaseI in Genome Data Viewer
Location:
96B17-96B18; 3-86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25040427..25045151, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20866149..20870873, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Smg6 Neighboring gene YTH N6-methyladenosine RNA binding protein Neighboring gene uncharacterized protein Neighboring gene baiser Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder. Fernandez A, et al. Am J Med Genet A, 2021 Jun. PMID 33720513
  2. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
  3. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
  4. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article
  5. Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. VoSSfeldt H, et al. PLoS One, 2012. PMID 23139745, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables inositol-polyphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-polyphosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
inositol polyphosphate-5-phosphatase type I
Names
5PtaseI-PB
5PtaseI-PC
5PtaseI-PG
CG42283-PB
CG42283-PC
CG42283-PG
NP_001138108.1
NP_001356900.1
NP_733069.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25040427..25045151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170190.2 → NP_733069.1  inositol polyphosphate-5-phosphatase type I, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMU3, Q8T8Q6
    Related
    FBpp0288935
    Conserved Domains (1) summary
    cd09092
    Location:11 → 382
    INPP5A; Type I inositol polyphosphate 5-phosphatase I

  2. NM_001370014.1 → NP_001356900.1  inositol polyphosphate-5-phosphatase type I, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0Q1
    Conserved Domains (1) summary
    cd09092
    Location:11 → 390
    INPP5A; Type I inositol polyphosphate 5-phosphatase I

  3. NM_001144636.2 → NP_001138108.1  inositol polyphosphate-5-phosphatase type I, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0Q2, Q8IGM4
    Conserved Domains (1) summary
    cd09092
    Location:11 → 390
    INPP5A; Type I inositol polyphosphate 5-phosphatase I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z0Q1 B7Z0Q1
B7Z0Q2 B7Z0Q2
Q8IGM4 Q8IGM4
Q8IMU3 Q8IMU3
Q8T8Q6 Q8T8Q6

Gene LinkOut

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