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HDAC11 Histone deacetylase 11 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326120, updated on 9-Dec-2024

Summary

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Official Symbol
HDAC11provided by FlyBase
Official Full Name
Histone deacetylase 11provided by FlyBase
Primary source
FLYBASE:FBgn0051119
Locus tag
Dmel_CG31119
See related
AllianceGenome:FB:FBgn0051119
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31119; dHDAC11; DHDACX; Dmel\CG31119; dmHDA403; Hdac11; HdacX; HDACX
Summary
Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC11 (histone deacetylase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See HDAC11 in Genome Data Viewer
Location:
96B1-96B1; 3-86 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24854496..24856243, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20680218..20681965, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Epidermal stripes and patches Neighboring gene uncharacterized protein Neighboring gene Nicastrin Neighboring gene Carbonic anhydrase 4 Neighboring gene pickpocket 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. Todd PK, et al. PLoS Genet, 2010 Dec 9. PMID 21170301, Free PMC Article
  2. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Pallos J, et al. Hum Mol Genet, 2008 Dec 1. PMID 18762557, Free PMC Article
  3. The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory. Perry S, et al. Cell Rep, 2017 Feb 7. PMID 28178513, Free PMC Article
  4. Role of histone deacetylases in gene regulation at nuclear lamina. Milon BC, et al. PLoS One, 2012. PMID 23226217, Free PMC Article
  5. Nuclear position and local acetyl-CoA production regulate chromatin state. Willnow P, et al. Nature, 2024 Jun. PMID 38839952, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
    Title: Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone deacetylase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone deacetylase 11
Names
CG31119-PA
CG31119-PB
HDAC11-PA
HDAC11-PB
histone deacetylase X
NP_001247296.1
NP_733048.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24854496..24856243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260367.1 → NP_001247296.1  histone deacetylase 11, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V4I3, Q9VC26
    Conserved Domains (1) summary
    cd09993
    Location:51 → 336
    HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11

  2. NM_170173.3 → NP_733048.1  histone deacetylase 11, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733048.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V4I3, Q9VC26
    Related
    FBpp0084109
    Conserved Domains (1) summary
    cd09993
    Location:51 → 336
    HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VC26 Q9VC26

Gene LinkOut

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