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CG31445 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326140, updated on 9-Dec-2024

Summary

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Official Symbol
CG31445provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0051445
Locus tag
Dmel_CG31445
See related
AllianceGenome:FB:FBgn0051445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11955; Dmel\CG31445
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Orthologous to several human genes including ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG31445 in Genome Data Viewer
Location:
99A1-99A4; 3-98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29240580..29244827, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25066302..25070549, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene SP1029 Neighboring gene string

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
  2. Su(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activation. Khan A, et al. PLoS One, 2009. PMID 19333393, Free PMC Article
  3. Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila. Ma Z, et al. Elife, 2024 Sep 10. PMID 39255019, Free PMC Article
  4. Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila. Kuuluvainen E, et al. J Biol Chem, 2014 Jun 6. PMID 24778181, Free PMC Article
  5. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG31445-PA
CG31445-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29240580..29244827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276135.1 → NP_001263064.1  uncharacterized protein Dmel_CG31445, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SR0
    Conserved Domains (3) summary
    cd09601
    Location:43 → 497
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:28 → 426
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:578 → 904
    ERAP1_C; ERAP1-like C-terminal domain

  2. NM_143432.3 → NP_651689.1  uncharacterized protein Dmel_CG31445, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SR0
    Related
    FBpp0084770
    Conserved Domains (3) summary
    cd09601
    Location:43 → 497
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:28 → 426
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:578 → 904
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SR0 Q95SR0

Gene LinkOut

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