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ninaD neither inactivation nor afterpotential D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326160, updated on 9-Dec-2024

Summary

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Official Symbol
ninaDprovided by FlyBase
Official Full Name
neither inactivation nor afterpotential Dprovided by FlyBase
Primary source
FLYBASE:FBgn0002939
Locus tag
Dmel_CG31783
See related
AllianceGenome:FB:FBgn0002939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31783; CG5750; Dmel\CG31783; Ninad; NINAD
Summary
Enables scavenger receptor activity. Involved in carotenoid transport; phototransduction; and rhodopsin biosynthetic process. Predicted to be active in membrane. Is expressed in several structures, including adult brain; anterior-posterior subdivision of organism; embryonic/larval fat body; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ninaD in Genome Data Viewer
Location:
36E3-36E3; 2-53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18081628..18083608)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18081628..18083608)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene reduced ocelli Neighboring gene Arrestin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila class B scavenger receptor NinaD-I is a cell surface receptor mediating carotenoid transport for visual chromophore synthesis. Voolstra O, et al. Biochemistry, 2006 Nov 14. PMID 17087496
  2. A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila. Kiefer C, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12136129, Free PMC Article
  3. A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism. Gomez-Diaz C, et al. Nat Commun, 2016 Jun 15. PMID 27302750, Free PMC Article
  4. Electrophysiological study of Drosophila rhodopsin mutants. Johnson EC, et al. J Gen Physiol, 1986 Nov. PMID 3097245, Free PMC Article
  5. Cellular sites of Drosophila NinaB and NinaD activity in vitamin A metabolism. Yang J, et al. Mol Cell Neurosci, 2007 May. PMID 17344064

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ninaD gene encodes a class B scavenger receptor essential for the formation of the visual chromophore; mediates the cellular uptake of carotenoids
    Title: A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila.
  2. we provide evidence of an essential role of NinaD-I in the absorption of dietary carotenoids to support visual chromophore synthesis. Moreover, our analyses suggest a role of NinaD-I in tocopherol metabolism.
    Title: The Drosophila class B scavenger receptor NinaD-I is a cell surface receptor mediating carotenoid transport for visual chromophore synthesis.
  3. Beta-carotene is transported to the adult brain, where cellular uptake by NinaD allows cleavage by the NinaB enzyme to produce retinal
    Title: Cellular sites of Drosophila NinaB and NinaD activity in vitamin A metabolism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables scavenger receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables scavenger receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in carotenoid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carotenoid transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, visible light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhodopsin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neither inactivation nor afterpotential D
Names
CG31783-PA
CG31783-PB
ninaD-PA
ninaD-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18081628..18083608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165237.2 → NP_724087.1  neither inactivation nor afterpotential D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724087.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7X2, Q8INY3
    Related
    FBpp0080584
    Conserved Domains (1) summary
    pfam01130
    Location:19 → 474
    CD36; CD36 family

  2. NM_001201907.2 → NP_001188836.1  neither inactivation nor afterpotential D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188836.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRL5, Q8I7X2
    Conserved Domains (1) summary
    pfam01130
    Location:19 → 415
    CD36; CD36 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MRL5 M9MRL5
Q8I7X2 Q8I7X2
Q8INY3 Q8INY3
Q8MS21 Q8MS21

Gene LinkOut

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