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Cubn Cubilin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326235, updated on 4-Jan-2025

Summary

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Official Symbol
Cubnprovided by FlyBase
Official Full Name
Cubilinprovided by FlyBase
Primary source
FLYBASE:FBgn0052702
Locus tag
Dmel_CG32702
See related
AllianceGenome:FB:FBgn0052702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like
Summary
Enables cargo receptor activity. Involved in clathrin-dependent endocytosis; nephrocyte filtration; and renal protein absorption. Part of receptor complex. Is expressed in adult head; adult heart; embryonic/larval garland cell; larval pericardial cell; and spermatozoon. Used to study kidney disease. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cubn in Genome Data Viewer
Location:
8E7-8E10; 1-28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9558665..9571308, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9452698..9465341, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42767 Neighboring gene Ribosomal protein S28b Neighboring gene uncharacterized protein Neighboring gene Lysophosphatidylcholine acyltransferase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45540

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cubilin and amnionless mediate protein reabsorption in Drosophila nephrocytes. Zhang F, et al. J Am Soc Nephrol, 2013 Feb. PMID 23264686, Free PMC Article
  2. dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity. Feng X, et al. Dis Model Mech, 2021 Sep 1. PMID 34437681, Free PMC Article
  3. A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter. Tao Y, et al. PLoS Biol, 2007 Nov 6. PMID 17988173, Free PMC Article
  4. Proliferation and dissemination of killer meiotic drive loci. Lai EC, et al. Curr Opin Genet Dev, 2023 Oct. PMID 37625205, Free PMC Article
  5. An evolutionary expressed sequence tag analysis of Drosophila spermatheca genes. Prokupek A, et al. Evolution, 2008 Nov. PMID 18752616

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nephrocyte filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in renal protein absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
cubilin
Names
CG32702-PB
Cubn-PB
TMPRSS6 iron sensing
cubilin ortholog
dCubilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9558665..9571308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167193.2 → NP_727348.2  cubilin [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727348.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T4G4, Q9W332
    Conserved Domains (6) summary
    smart00179
    Location:282 → 322
    EGF_CA; Calcium-binding EGF-like domain
    cd00041
    Location:1100 → 1211
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00054
    Location:192 → 233
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:430 → 457
    EGF; EGF-like domain
    pfam12947
    Location:328 → 366
    EGF_3; EGF domain
    cl00049
    Location:744 → 849
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W332.3 Q9W332

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