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Targ2 Terminal ADP-ribose protein glycohydrolase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326246, updated on 9-Dec-2024

Summary

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Official Symbol
Targ2provided by FlyBase
Official Full Name
Terminal ADP-ribose protein glycohydrolase 2provided by FlyBase
Primary source
FLYBASE:FBgn0053056
Locus tag
Dmel_CG33056
See related
AllianceGenome:FB:FBgn0053056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10517; CG33056; Dmel\CG33056; dTarg2
Summary
Predicted to enable ADP-ribosyl-[dinitrogen reductase] hydrolase activity; ADP-ribosylglutamate hydrolase activity; and purine nucleoside binding activity. Predicted to be involved in DNA damage response and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Is expressed in several structures, including adult brain; adult pars intercerebralis; embryonic dorsal epidermis; embryonic esophagus; and embryonic hypopharynx. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Targ2 in Genome Data Viewer
Location:
78C2-78C2; 3-47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21198261..21203232, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21191361..21196332, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45951 Neighboring gene parkin Neighboring gene Terminal ADP-ribose protein glycohydrolase 3 Neighboring gene Terminal ADP-ribose protein glycohydrolase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA methyltransferase subunit 11-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Fontana P, et al. Nat Commun, 2023 Jun 2. PMID 37268618, Free PMC Article
  2. Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase. Bu S, et al. Cell Rep, 2022 May 31. PMID 35649352
  3. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489
  4. A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification. Li Y, et al. Nat Commun, 2024 Mar 6. PMID 38448482, Free PMC Article
  5. A gene-specific T2A-GAL4 library for Drosophila. Lee PT, et al. Elife, 2018 Mar 22. PMID 29565247, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-ribosylglutamate hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables purine nucleoside binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleoside metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleoside metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
terminal ADP-ribose protein glycohydrolase 2
Names
CG33056-PA
CG33056-PB
CG33056-PC
CG33056-PD
CG33056-PE
Targ2-PA
Targ2-PB
Targ2-PC
Targ2-PD
Targ2-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21198261..21203232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176378.2 → NP_788556.1  terminal ADP-ribose protein glycohydrolase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM2, Q961L8
    Related
    FBpp0077967
    Conserved Domains (1) summary
    cd02901
    Location:160 → 289
    Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

  2. NM_176379.2 → NP_788557.1  terminal ADP-ribose protein glycohydrolase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788557.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM2, Q961L8
    Related
    FBpp0077968
    Conserved Domains (1) summary
    cd02901
    Location:160 → 289
    Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

  3. NM_176381.2 → NP_788559.1  terminal ADP-ribose protein glycohydrolase 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788559.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM2, Q961L8
    Related
    FBpp0077971
    Conserved Domains (1) summary
    cd02901
    Location:160 → 289
    Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

  4. NM_176377.2 → NP_788555.1  terminal ADP-ribose protein glycohydrolase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788555.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM2, Q86BG8
    Related
    FBpp0077969
    Conserved Domains (2) summary
    cd02901
    Location:137 → 266
    Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    cl00019
    Location:5 → 100
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

  5. NM_176380.2 → NP_788558.1  terminal ADP-ribose protein glycohydrolase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788558.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM2, Q961L8
    Related
    FBpp0077970
    Conserved Domains (1) summary
    cd02901
    Location:160 → 289
    Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BG8 Q86BG8
Q961L8 Q961L8

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