U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spn28Db Serpin 28Db [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326261, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Spn28Dbprovided by FlyBase
Official Full Name
Serpin 28Dbprovided by FlyBase
Primary source
FLYBASE:FBgn0053121
Locus tag
Dmel_CG33121
See related
AllianceGenome:FB:FBgn0053121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12318; CG33121; Dmel\CG33121
Summary
Involved in sexual reproduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in intermediate coronary syndrome; neurodegenerative disease (multiple); thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Spn28Db in Genome Data Viewer
Location:
28D2-28D2; 2-29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7889288..7890704, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7889288..7890594, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serpin 28Da Neighboring gene Sno oncogene Neighboring gene uncharacterized protein Neighboring gene peste

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Intermolecular Interactions Drive Protein Adaptive and Coadaptive Evolution at Both Species and Population Levels. Peng J, et al. Mol Biol Evol, 2022 Jan 7. PMID 34878126, Free PMC Article
  2. Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster. Sepil I, et al. Mol Cell Proteomics, 2019 Mar 15. PMID 30287546, Free PMC Article
  3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
  4. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
  5. FlyXCDB-A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains. Pei J, et al. J Mol Biol, 2018 Sep 14. PMID 29890119

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables serine-type endopeptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serpin 28Db
Names
CG33121-PB
Spn28Db-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7889288..7890704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370007.1 → NP_001356884.1  serpin 28Db [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLV3
    Conserved Domains (1) summary
    cd00172
    Location:22 → 368
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLV3 Q9VLV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools