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CG9673 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32649, updated on 9-Dec-2024

Summary

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Official Symbol
CG9673provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030775
Locus tag
Dmel_CG9673
See related
AllianceGenome:FB:FBgn0030775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG9673; SPH81
Summary
Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic midgut chamber and embryonic/larval midgut. Orthologous to human PRSS54 (serine protease 54). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG9673 in Genome Data Viewer
Location:
15A2-15A3; 1-55 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16702786..16703884, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16596819..16597917, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spheroide Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The serine protease homolog spheroide is involved in sensing of pathogenic Gram-positive bacteria. Patrnogic J, et al. PLoS One, 2017. PMID 29211760, Free PMC Article
  2. Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Blount JR, et al. Biol Open, 2019 May 30. PMID 31097444, Free PMC Article
  3. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article
  4. Drosophila melanogaster larval hemolymph protein mapping. Guedes Sde M, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680800
  5. Evolution of a cellular immune response in Drosophila: a phenotypic and genomic comparative analysis. Salazar-Jaramillo L, et al. Genome Biol Evol, 2014 Feb. PMID 24443439, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG9673-PA
CG9673-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16702786..16703884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298417.1 → NP_001285346.1  uncharacterized protein Dmel_CG9673, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285346.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXC7
    Conserved Domains (2) summary
    smart00020
    Location:28 → 256
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29 → 259
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_132921.3 → NP_573149.1  uncharacterized protein Dmel_CG9673, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573149.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXC7
    Related
    FBpp0074136
    Conserved Domains (2) summary
    smart00020
    Location:28 → 256
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29 → 259
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXC7 Q9VXC7

Gene LinkOut

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