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Sap30 SIN3-associated polypeptide 30 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32664, updated on 2-Nov-2024

Summary

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Official Symbol
Sap30provided by FlyBase
Official Full Name
SIN3-associated polypeptide 30provided by FlyBase
Primary source
FLYBASE:FBgn0030788
Locus tag
Dmel_CG4756
See related
AllianceGenome:FB:FBgn0030788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg4756; CG4756; Dmel\CG4756; SAP30
Summary
Predicted to enable transcription coregulator activity. Involved in regulation of G2/M transition of mitotic cell cycle. Predicted to be part of histone deacetylase complex. Is expressed in organism. Orthologous to several human genes including SAP30L (SAP30 like). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Sap30 in Genome Data Viewer
Location:
15A8-15A8; 1-55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16787283..16789644)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16681316..16683677)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene uncharacterized protein Neighboring gene Rrp45 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rat1 Interacting Protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels. Pile LA, et al. Mol Cell Biol, 2002 Jul. PMID 12077326, Free PMC Article
  2. Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. Larschan E, et al. PLoS Genet, 2012. PMID 22844249, Free PMC Article
  3. Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Lee CY, et al. Curr Biol, 2003 Feb 18. PMID 12593803
  4. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828
  5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone deacetylase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
SIN3-associated polypeptide 30
Names
CG4756-PA
CG4756-PB
Sap30-PA
Sap30-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16787283..16789644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298423.1 → NP_001285352.1  SIN3-associated polypeptide 30, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285352.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VXB3
    UniProtKB/TrEMBL
    X2JKS9
    Conserved Domains (2) summary
    pfam13866
    Location:16 → 86
    zf-SAP30; SAP30 zinc-finger
    pfam13867
    Location:104 → 156
    SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30

  2. NM_132934.4 → NP_573162.1  SIN3-associated polypeptide 30, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573162.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VXB3
    UniProtKB/TrEMBL
    X2JKS9
    Related
    FBpp0074105
    Conserved Domains (2) summary
    pfam13866
    Location:16 → 86
    zf-SAP30; SAP30 zinc-finger
    pfam13867
    Location:104 → 156
    SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXB3.1 Q9VXB3
X2JKS9 X2JKS9

Gene LinkOut

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