U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ppk28 pickpocket 28 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32671, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ppk28provided by FlyBase
Official Full Name
pickpocket 28provided by FlyBase
Primary source
FLYBASE:FBgn0030795
Locus tag
Dmel_CG4805
See related
AllianceGenome:FB:FBgn0030795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4805; Dmel\CG4805; ppk-28; PPK-28; Ppk28; PPK28
Summary
Predicted to enable ligand-gated sodium channel activity. Involved in cellular response to water stimulus; drinking behavior; and liquid clearance, open tracheal system. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in eo-type sensillum; gustatory receptor neurons; primary tracheal branch; and tracheal tip cell. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ppk28 in Genome Data Viewer
Location:
15A9-15A10; 1-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16806068..16808515)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16700101..16702548)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44053 Neighboring gene Rat1 Interacting Protein 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44129 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections. Touré H, et al. Infect Immun, 2023 Nov 16. PMID 37847031, Free PMC Article
  2. Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Waterson MJ, et al. Proc Natl Acad Sci U S A, 2014 Jun 3. PMID 24821805, Free PMC Article
  3. The molecular basis for water taste in Drosophila. Cameron P, et al. Nature, 2010 May 6. PMID 20364123, Free PMC Article
  4. Drosophila gustatory projections are segregated by taste modality and connectivity. Engert S, et al. Elife, 2022 May 25. PMID 35611959, Free PMC Article
  5. Long-range projection neurons in the taste circuit of Drosophila. Kim H, et al. Elife, 2017 Feb 6. PMID 28164781, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results confirm a role for ppk28 in promoting water consumption in drosophila.
    Title: A simple high throughput assay to evaluate water consumption in the fruit fly.
  2. We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan.
    Title: Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling.
  3. the amiloride-sensitive PPK28 channel may serve as the osmolarity sensor for gustatory water reception in the fruit fly.
    Title: The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception.
  4. a member of the degenerin/epithelial sodium channel family, PPK28, as an osmosensitive ion channel that mediates the cellular and behavioural response to water
    Title: The molecular basis for water taste in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to water stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in drinking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to water IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
pickpocket 28
Names
CG4805-PA
ppk28-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16806068..16808515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132941.3 → NP_573169.2  pickpocket 28 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573169.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86LG0, Q86LG1, Q9VXA6
    Conserved Domains (1) summary
    pfam00858
    Location:43 → 509
    ASC; Amiloride-sensitive sodium channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86LG1.2 Q86LG1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous