cnbpa CCHC-type zinc finger, nucleic acid binding protein a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cnbpaprovided by ZNC
Official Full Name: CCHC-type zinc finger, nucleic acid binding protein aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5045
See related: Ensembl:ENSDARG00000045776 AllianceGenome:ZFIN:ZDB-GENE-030131-5045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zff9; zCNBP; fe36b09; zgc:63625; wu:fe36b09
Summary: Enables chromatin binding activity and nucleic acid binding activity. Acts upstream of or within several processes, including neural crest cell fate specification; regulation of DNA-templated transcription; and skeletal system development. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (4699148..4705240, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (4763275..4769367, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CNBP controls transcription by unfolding DNA G-quadruplex structures.
Title: CNBP controls transcription by unfolding DNA G-quadruplex structures.
Zebrafish cnbp intron1 plays a fundamental role in controlling spatiotemporal gene expression during embryonic development.
Title: Zebrafish cnbp intron1 plays a fundamental role in controlling spatiotemporal gene expression during embryonic development.
CNBP mediates neural crest cell expansion by controlling cell proliferation and cell survival during rostral head development.
Title: CNBP mediates neural crest cell expansion by controlling cell proliferation and cell survival during rostral head development.
phosphorylation might be a conserved post-translational modification that allows CNBP to perform a fine tune expression regulation of a group of target genes, during embryogenesis
Title: In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities.
Findings suggest that zCNBP is a strikingly conserved single-stranded nucleic acid-binding protein which might interact with maternal mRNA during its storage in the embryo cell cytoplasm.
Title: Zebrafish cellular nucleic acid-binding protein: gene structure and developmental behaviour.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within head development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CCHC-type zinc finger, nucleic acid binding protein a

Names: CNBP; cellular nucleic acid binding protein; zinc finger protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244736.1 → NP_001231665.1 CCHC-type zinc finger, nucleic acid binding protein a

See identical proteins and their annotated locations for NP_001231665.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

EH501940, EH531056

UniProtKB/TrEMBL

A0A8M1NYR9, F1Q6Z5

Conserved Domains (1) summary

PTZ00368
Location:40 → 157

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
NM_199749.2 → NP_956043.2 CCHC-type zinc finger, nucleic acid binding protein a

See identical proteins and their annotated locations for NP_956043.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

CU571070

UniProtKB/TrEMBL

A0A8M1NYR9, F1Q6Z5

Related

ENSDARP00000067292.4, ENSDART00000067293.6

Conserved Domains (1) summary

PTZ00368
Location:40 → 157

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional