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wcy wacky [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32690, updated on 4-Jan-2025

Summary

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Official Symbol
wcyprovided by FlyBase
Official Full Name
wackyprovided by FlyBase
Primary source
FLYBASE:FBgn0030812
Locus tag
Dmel_CG8949
See related
AllianceGenome:FB:FBgn0030812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BP1032; CG34014; CG8949; Dmel\CG8949; XE14
Summary
Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Involved in habituation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Located in lysosome and nucleus. Is expressed in embryonic/larval fat body. Used to study DeSanto-Shinawi syndrome. Human ortholog(s) of this gene implicated in DeSanto-Shinawi syndrome. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See wcy in Genome Data Viewer
Location:
15E1-15E1; 1-57 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17068717..17077897, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16962750..16971930, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila. Lugtenberg D, et al. Eur J Hum Genet, 2016 Aug. PMID 26757981, Free PMC Article
  2. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Xu GM, et al. Genomics, 2002 Jan. PMID 11827461
  3. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Kepler LD, et al. Neurobiol Learn Mem, 2020 May. PMID 32147587
  4. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. David-Morrison G, et al. Dev Cell, 2016 Jan 25. PMID 26812014, Free PMC Article
  5. The gut-microbiota-brain axis in autism: what Drosophila models can offer? Salim S, et al. J Neurodev Disord, 2021 Sep 15. PMID 34525941, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal knockdown of Drosophila CG8949 resulted in impaired learning.
    Title: De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in habituation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
wacky
Names
CG8949-PA
CG8949-PC
CG8949-PD
CG8949-PE
CG8949-PF
CG8949-PG
wcy-PA
wcy-PC
wcy-PD
wcy-PE
wcy-PF
wcy-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17068717..17077897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258796.2 → NP_001245725.1  wacky, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245725.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q32KD5, Q9VX88
    Conserved Domains (1) summary
    cd00201
    Location:242 → 271
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  2. NM_132959.3 → NP_573187.2  wacky, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573187.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q32KD5, Q9VX88
    Conserved Domains (1) summary
    cd00201
    Location:242 → 271
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  3. NM_001272708.1 → NP_001259637.1  wacky, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259637.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHX3
    Conserved Domains (1) summary
    cd00201
    Location:242 → 271
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  4. NM_001103538.4 → NP_001097008.2  wacky, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097008.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    R9PY73
    Conserved Domains (1) summary
    cd00201
    Location:242 → 271
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  5. NM_001272706.2 → NP_001259635.1  wacky, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259635.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEY4
    Conserved Domains (1) summary
    cd00201
    Location:242 → 271
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  6. NM_001272707.1 → NP_001259636.1  wacky, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259636.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHE3
    Conserved Domains (1) summary
    cd00201
    Location:284 → 313
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEY4 M9PEY4
M9PHE3 M9PHE3
M9PHX3 M9PHX3
Q9VX88.2 Q9VX88
R9PY73 R9PY73

Gene LinkOut

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