Fim - Fimbrin

Predicted to enable actin filament binding activity. Involved in actin crosslink formation; cortical actin cytoskeleton organization; and syncytial embryo cellularization. Located in apical cortex and cytosol. Colocalizes with contractile ring. Is expressed in adult brain; adult brain cell body rind; adult gnathal ganglion; adult head; and adult optic lobe. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76; congenital diaphragmatic hernia; and nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1); PLS1 (plastin 1); and PLS3 (plastin 3). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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