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rgs14a regulator of G protein signaling 14a [ Danio rerio (zebrafish) ]

Gene ID: 327368, updated on 4-Jan-2025

Summary

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Official Symbol
rgs14aprovided by ZNC
Official Full Name
regulator of G protein signaling 14aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5579
See related
Ensembl:ENSDARG00000021521 AllianceGenome:ZFIN:ZDB-GENE-030131-5579
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rgs14; wu:fi04g12
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within germ cell migration. Is expressed in blastomere; epidermis; neural crest; and primordial germ cell. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See rgs14a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (871739..899155, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (853475..880891, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1a Neighboring gene si:ch73-302a4.4 Neighboring gene uncharacterized LOC103912050 Neighboring gene ADP ribosylation factor like GTPase 3, like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Aggregation, segregation, and dispersal of homotypic germ plasm RNPs in the early zebrafish embryo. Eno C, et al. Dev Dyn, 2019 Apr. PMID 30741457, Free PMC Article
  2. CFTR is required for the migration of primordial germ cells during zebrafish early embryogenesis. Liao H, et al. Reproduction, 2018 Sep. PMID 29930176, Free PMC Article
  3. Conserved germ plasm characteristics across the Danio and Devario lineages. Hansen CL, et al. Genesis, 2021 Oct. PMID 34617657, Free PMC Article
  4. Temporal control over the initiation of cell motility by a regulator of G-protein signaling. Hartwig J, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049415, Free PMC Article
  5. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. Zhang X, et al. PLoS One, 2019. PMID 31412047, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 14a
Names
regulator of G-protein signalling 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201304.1 → NP_958461.1  regulator of G-protein signaling 14a

    See identical proteins and their annotated locations for NP_958461.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055659
    UniProtKB/TrEMBL
    A0A8M3B8C4, Q7SXC7
    Related
    ENSDARP00000033675.5, ENSDART00000031992.7
    Conserved Domains (4) summary
    cd01817
    Location:321 → 393
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08706
    Location:87 → 201
    RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
    pfam02188
    Location:486 → 507
    GoLoco; GoLoco motif
    cl00155
    Location:401 → 461
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    871739..899155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307644.4 → XP_009305919.3  regulator of G-protein signaling 14a isoform X1

    UniProtKB/TrEMBL
    A0A8M3B8C4
Nucleotide Protein Strain
Heading Accession and Version

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