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IntS2 Integrator 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32745, updated on 4-Jan-2025

Summary

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Official Symbol
IntS2provided by FlyBase
Official Full Name
Integrator 2provided by FlyBase
Primary source
FLYBASE:FBgn0030858
Locus tag
Dmel_CG8211
See related
AllianceGenome:FB:FBgn0030858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8211; Dmel\CG8211; Int2; intS2
Summary
Involved in positive regulation of gene expression; positive regulation of neuron differentiation; and snRNA 3'-end processing. Part of integrator complex. Is active in nucleus. Orthologous to human INTS2 (integrator complex subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See IntS2 in Genome Data Viewer
Location:
16B10-16B10; 1-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17652761..17656818, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17546794..17550851, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein p190 Neighboring gene uncharacterized protein Neighboring gene beta Spectrin Neighboring gene uncharacterized protein Neighboring gene chascon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells. Zhang Y, et al. Cell Rep, 2019 Apr 23. PMID 31018143
  2. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
  3. Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Jemc J, et al. Dev Biol, 2007 Oct 15. PMID 17714699, Free PMC Article
  4. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
  5. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Albrecht TR, et al. Nucleic Acids Res, 2018 May 4. PMID 29471365, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator 2
Names
CG8211-PA
IntS2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17652761..17656818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133004.2 → NP_573232.1  integrator 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573232.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VX31
    Related
    FBpp0074254
    Conserved Domains (1) summary
    pfam14750
    Location:21 → 1054
    INTS2; Integrator complex subunit 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VX31.2 Q9VX31

Gene LinkOut

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