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unc-4 unc-4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32757, updated on 9-Dec-2024

Summary

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Official Symbol
unc-4provided by FlyBase
Official Full Name
unc-4provided by FlyBase
Primary source
FLYBASE:FBgn0024184
Locus tag
Dmel_CG6269
See related
AllianceGenome:FB:FBgn0024184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6269; Dmel\CG6269; DPHD-1; Dunc-4; Unc-4; Unc4
Summary
Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of gene expression. Is expressed in several structures, including genitalia; imaginal disc; motor neurons; segmentally-repeated neuroblast; and sensory neurons. Orthologous to human UNCX (UNC homeobox). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See unc-4 in Genome Data Viewer
Location:
16C10-16D1; 1-58 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17768569..17778708)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17662602..17672741)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene raskol Neighboring gene Ods-site homeobox Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells. Tabuchi K, et al. Neurosci Lett, 1998 Nov 20. PMID 9857963
  2. A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH). Nunes WVB, et al. G3 (Bethesda), 2024 Mar 6. PMID 38156703, Free PMC Article
  3. Sex and speciation: Drosophila reproductive tract proteins- twenty five years later. Singh R, et al. Int J Evol Biol, 2012. PMID 23119225, Free PMC Article
  4. Speciation and changes in male gene expression in Drosophila. Patlar B, et al. Genome, 2021 Feb. PMID 32730707
  5. Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS. Lacin H, et al. Elife, 2020 Mar 27. PMID 32216875, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
unc-4
Names
CG6269-PB
CG6269-PC
CG6269-PD
paired HomeoDomain 1
unc-4-PB
unc-4-PC
unc-4-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17768569..17778708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133014.3 → NP_573242.2  unc-4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573242.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77215, Q058S3
    UniProtKB/TrEMBL
    X2JFX5
    Conserved Domains (2) summary
    pfam00046
    Location:246 → 299
    Homeobox; Homeobox domain
    cl17190
    Location:327 → 368
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. NM_001298461.1 → NP_001285390.1  unc-4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285390.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCE2
    Conserved Domains (1) summary
    pfam00046
    Location:246 → 289
    Homeobox; Homeobox domain

  3. NM_001298460.1 → NP_001285389.1  unc-4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285389.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77215, Q058S3
    UniProtKB/TrEMBL
    X2JFX5
    Conserved Domains (2) summary
    pfam00046
    Location:246 → 299
    Homeobox; Homeobox domain
    cl17190
    Location:327 → 368
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77215.2 O77215
X2JCE2 X2JCE2
X2JFX5 X2JFX5

Gene LinkOut

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