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Socs16D Suppressor of Cytokine Signaling at 16D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32760, updated on 9-Dec-2024

Summary

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Official Symbol
Socs16Dprovided by FlyBase
Official Full Name
Suppressor of Cytokine Signaling at 16Dprovided by FlyBase
Primary source
FLYBASE:FBgn0030869
Locus tag
Dmel_CG8146
See related
AllianceGenome:FB:FBgn0030869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8146; Dmel\CG8146; dmSocs16D; SOCS; Socs 16D; socs16D; SOCS16D; Socs16E
Summary
Enables myosin binding activity. Involved in positive regulation of TORC1 signaling and vascular endothelial growth factor receptor signaling pathway. Is expressed in follicle cell. Orthologous to human SOCS7 (suppressor of cytokine signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Socs16D in Genome Data Viewer
Location:
16D4-16D4; 1-58 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17820764..17827564, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17714797..17721597, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ods-site homeobox Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44691 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary. Monahan AJ, et al. Dev Biol, 2013 Jul 15. PMID 23583584, Free PMC Article
  2. Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities. Rawlings JS, et al. BMC Cell Biol, 2004 Oct 15. PMID 15488148, Free PMC Article
  3. Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes. Kind J, et al. Genes Dev, 2007 Aug 15. PMID 17699750, Free PMC Article
  4. The fertile field of Drosophila Jak/STAT signalling. Hombría JC, et al. Curr Biol, 2002 Aug 20. PMID 12194841
  5. Drosophila SOCS Proteins. Stec WJ, et al. J Signal Transduct, 2011. PMID 22203896, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables myosin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
suppressor of cytokine signaling at 16D
Names
CG8146-PA
CG8146-PB
Socs16D-PA
Socs16D-PB
suppressor of cytokine signaling at 16E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17820764..17827564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272733.2 → NP_001259662.1  suppressor of cytokine signaling at 16D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHY7
    Conserved Domains (2) summary
    cd10388
    Location:839 → 937
    SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03741
    Location:960 → 1009
    SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...

  2. NM_078666.4 → NP_523390.3  suppressor of cytokine signaling at 16D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523390.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX18
    Conserved Domains (2) summary
    cd10388
    Location:834 → 932
    SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03741
    Location:955 → 1004
    SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHY7 M9PHY7
Q9VX18 Q9VX18

Gene LinkOut

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