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Ucp4A Uncoupling protein 4A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32764, updated on 4-Jan-2025

Summary

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Official Symbol
Ucp4Aprovided by FlyBase
Official Full Name
Uncoupling protein 4Aprovided by FlyBase
Primary source
FLYBASE:FBgn0030872
Locus tag
Dmel_CG6492
See related
AllianceGenome:FB:FBgn0030872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6492; Dmel\CG6492; dmUCP4a; DmUCP4A; ucp-4a; ucp4a; ucp4A; Ucp4a; UCP4A
Summary
Enables L-aspartate transmembrane transporter activity and uniporter activity. Involved in aspartate transmembrane transport; mitochondrial transmembrane transport; and response to oxidative stress. Is active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ucp4A in Genome Data Viewer
Location:
16E1-16E1; 1-59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17844949..17848223)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17738982..17742256)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44691 Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spt7 Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate. Lunetti P, et al. Int J Mol Sci, 2022 Jan 18. PMID 35162943, Free PMC Article
  2. Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's disease. Imai Y, et al. Commun Biol, 2019. PMID 31799427, Free PMC Article
  3. Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein. Hanák P, et al. FEBS Lett, 2001 Apr 27. PMID 11334880
  4. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. Da-Ré C, et al. EMBO Rep, 2014 May. PMID 24639557, Free PMC Article
  5. Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Bell O, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20562853

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate.
    Title: Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate.
  2. results indicate that UCP4A prevents mitochondrial dysfunction and that modulation of UCP activity protects cells in a situation relevant for human Parkinson's disease
    Title: UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uniporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in aspartate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncoupling protein 4A
Names
CG6492-PA
CG6492-PB
CG6492-PC
Ucp4A-PA
Ucp4A-PB
Ucp4A-PC
uncoupling Protein-4A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17844949..17848223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201735.2 → NP_001188664.1  uncoupling protein 4A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188664.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX14
    Conserved Domains (2) summary
    PTZ00169
    Location:39 → 335
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:248 → 336
    Mito_carr; Mitochondrial carrier protein

  2. NM_133018.4 → NP_573246.1  uncoupling protein 4A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573246.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX14
    Related
    FBpp0074238
    Conserved Domains (2) summary
    PTZ00169
    Location:39 → 335
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:248 → 336
    Mito_carr; Mitochondrial carrier protein

  3. NM_001298463.1 → NP_001285392.1  uncoupling protein 4A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285392.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JL00
    Conserved Domains (1) summary
    pfam00153
    Location:39 → 81
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VX14 Q9VX14
X2JL00 X2JL00

Gene LinkOut

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