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CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 [ Bos taurus (domestic cattle) ]

Gene ID: 327667, updated on 1-Jan-2025

Summary

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Official Symbol
CACNB2provided by VGNC
Official Full Name
calcium voltage-gated channel auxiliary subunit beta 2provided by VGNC
Primary source
VGNC:VGNC:26684
See related
BGD:BT28775; Ensembl:ENSBTAG00000022000
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See CACNB2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (32568577..32994526)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene mannose receptor C-type 1 Neighboring gene solute carrier family 39 member 12 Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene enhancer of polycomb homolog 1 Neighboring gene kinesin family member 5B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells. Cahill AL, et al. J Neurosci, 2000 Mar 1. PMID 10684870, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit beta-2
Names
CAB2
calcium channel voltage-dependent subunit beta 2
calcium channel, voltage-dependent, beta 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175789.2 → NP_786983.1  voltage-dependent L-type calcium channel subunit beta-2

    See identical proteins and their annotated locations for NP_786983.1

    Status: PROVISIONAL

    Source sequence(s)
    AF174417
    UniProtKB/Swiss-Prot
    Q9MZL5
    UniProtKB/TrEMBL
    A0A3Q1MBH6
    Related
    ENSBTAP00000029344.3, ENSBTAT00000029344.4
    Conserved Domains (4) summary
    cd12040
    Location:57 → 125
    SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
    pfam00625
    Location:225 → 405
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:17 → 58
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:235 → 406
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    32568577..32994526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059892406.1 → XP_059748389.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X8

  2. XM_005214152.5 → XP_005214209.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X3

    UniProtKB/TrEMBL
    Q9MZL4
    Conserved Domains (4) summary
    cd12040
    Location:112 → 180
    SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
    pfam00625
    Location:242 → 422
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:72 → 113
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:252 → 423
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. XM_005214150.5 → XP_005214207.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9TW09, Q9MZL4
    Related
    ENSBTAP00000101362.1, ENSBTAT00000110321.1
    Conserved Domains (4) summary
    cd12040
    Location:112 → 180
    SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
    pfam00625
    Location:280 → 460
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:72 → 113
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:290 → 461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  4. XM_005214151.5 → XP_005214208.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X2

    UniProtKB/TrEMBL
    A0AAA9T5M7, Q9MZL4
    Related
    ENSBTAP00000091867.1, ENSBTAT00000115334.1
    Conserved Domains (4) summary
    cd12040
    Location:84 → 152
    SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
    pfam00625
    Location:252 → 432
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:44 → 85
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:262 → 433
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  5. XM_010811102.4 → XP_010809404.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MA95, A0A3Q1MK14
    Related
    ENSBTAP00000069538.1, ENSBTAT00000071974.2
    Conserved Domains (4) summary
    cd12040
    Location:68 → 136
    SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
    pfam00625
    Location:236 → 416
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:28 → 69
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:246 → 417
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  6. XM_005214154.5 → XP_005214211.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1MA95, A0AAA9RZP0
    Related
    ENSBTAP00000078121.1, ENSBTAT00000122827.1
    Conserved Domains (4) summary
    cd12040
    Location:58 → 126
    SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
    pfam00625
    Location:226 → 406
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:18 → 59
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:236 → 407
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  7. XM_059892404.1 → XP_059748387.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X7

    UniProtKB/TrEMBL
    A0A3Q1MA95, A0AAA9T2S9
    Related
    ENSBTAP00000090944.1, ENSBTAT00000122055.1

  8. XM_005214153.5 → XP_005214210.1  voltage-dependent L-type calcium channel subunit beta-2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1LVX8, A0A3Q1MA95
    Related
    ENSBTAP00000061585.1, ENSBTAT00000082900.2
    Conserved Domains (4) summary
    cd12040
    Location:64 → 132
    SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2
    pfam00625
    Location:232 → 412
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:24 → 65
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:242 → 413
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MZL5.1 GenPept UniProtKB/Swiss-Prot:Q9MZL5

Gene LinkOut

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