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CTSS cathepsin S [ Bos taurus (domestic cattle) ]

Gene ID: 327711, updated on 1-Jan-2025

Summary

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Official Symbol
CTSSprovided by VGNC
Official Full Name
cathepsin Sprovided by VGNC
Primary source
VGNC:VGNC:27818
See related
BGD:BT29006; Ensembl:ENSBTAG00000017135
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See CTSS in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (19981529..20004463)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene cathepsin K Neighboring gene cAMP-regulated phosphoprotein 19 Neighboring gene HORMA domain containing 1 Neighboring gene enhancer of rudimentary homolog Neighboring gene golgi phosphoprotein 3 like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B. Brömme D, et al. Biochem J, 1989 Dec 1. PMID 2604727, Free PMC Article
  2. Primary structure of bovine cathepsin S. Comparison to cathepsins L, H, B and papain. Wiederanders B, et al. FEBS Lett, 1991 Jul 29. PMID 1864368
  3. Bovine cathepsins S and L: isolation and amino acid sequences. Dolenc I, et al. Biol Chem Hoppe Seyler, 1992 Jul. PMID 1515067
  4. The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L. Ritonja A, et al. FEBS Lett, 1991 Jun 3. PMID 2044774
  5. Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease. Schechter I, et al. Biol Chem, 2011 Apr. PMID 21585286

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
    Title: Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC127029

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cathepsin S
NP_001028787.1
XP_010801305.1
XP_010801306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033615.2 → NP_001028787.1  cathepsin S precursor

    See identical proteins and their annotated locations for NP_001028787.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102245
    UniProtKB/Swiss-Prot
    P25326, Q3T0V8
    UniProtKB/TrEMBL
    A0AAF6Z3H7
    Related
    ENSBTAP00000022774.3, ENSBTAT00000022774.4
    Conserved Domains (2) summary
    pfam00112
    Location:115 → 329
    Peptidase_C1; Papain family cysteine protease
    pfam08246
    Location:28 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    19981529..20004463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010803003.4 → XP_010801305.1  cathepsin S isoform X1

    See identical proteins and their annotated locations for XP_010801305.1

    UniProtKB/Swiss-Prot
    P25326, Q3T0V8
    UniProtKB/TrEMBL
    A0AAF6Z3H7
    Conserved Domains (2) summary
    pfam00112
    Location:115 → 329
    Peptidase_C1; Papain family cysteine protease
    pfam08246
    Location:28 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

  2. XM_010803004.4 → XP_010801306.1  cathepsin S isoform X1

    See identical proteins and their annotated locations for XP_010801306.1

    UniProtKB/Swiss-Prot
    P25326, Q3T0V8
    UniProtKB/TrEMBL
    A0AAF6Z3H7
    Conserved Domains (2) summary
    pfam00112
    Location:115 → 329
    Peptidase_C1; Papain family cysteine protease
    pfam08246
    Location:28 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25326.2 GenPept UniProtKB/Swiss-Prot:P25326

Gene LinkOut

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