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RhoGAP16F Rho GTPase activating protein at 16F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32790, updated on 9-Dec-2024

Summary

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Official Symbol
RhoGAP16Fprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 16Fprovided by FlyBase
Primary source
FLYBASE:FBgn0030893
Locus tag
Dmel_CG7122
See related
AllianceGenome:FB:FBgn0030893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7122; Dmel\CG7122
Summary
Predicted to enable GTPase activator activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm and plasma membrane. Is expressed in primary tracheal branch. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12); ARHGAP27 (Rho GTPase activating protein 27); and ARHGAP9 (Rho GTPase activating protein 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See RhoGAP16F in Genome Data Viewer
Location:
16F6-16F6; 1-59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18093145..18097413)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17987178..17991446)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Swt1 RNA endoribonuclease Neighboring gene scully Neighboring gene Multivesicular body subunit 12 Neighboring gene TBP-associated factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
  2. Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses. Nath AS, et al. Cell Rep, 2022 Mar 1. PMID 35235794
  3. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Kim S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655012, Free PMC Article
  4. Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway. Billuart P, et al. Cell, 2001 Oct 19. PMID 11672527
  5. Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair. Nakamura M, et al. J Cell Biol, 2017 Dec 4. PMID 28923977, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein at 16F
Names
CG7122-PB
CG7122-PC
CG7122-PD
CG7122-PE
CG7122-PF
RhoGAP16F-PB
RhoGAP16F-PC
RhoGAP16F-PD
RhoGAP16F-PE
RhoGAP16F-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18093145..18097413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298472.1 → NP_001285401.1  Rho GTPase activating protein at 16F, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285401.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9UND9, Q9VWY8
    Conserved Domains (1) summary
    cd00159
    Location:306 → 487
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  2. NM_176755.3 → NP_788928.2  Rho GTPase activating protein at 16F, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788928.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9UND9, Q9VWY8
    Related
    FBpp0074287
    Conserved Domains (1) summary
    cd00159
    Location:306 → 487
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  3. NM_133039.5 → NP_573267.3  Rho GTPase activating protein at 16F, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573267.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9UND9, Q9VWY8
    Related
    FBpp0298030
    Conserved Domains (1) summary
    cd00159
    Location:306 → 487
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  4. NM_001258801.2 → NP_001245730.1  Rho GTPase activating protein at 16F, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9UND9, Q9VWY8
    Conserved Domains (1) summary
    cd00159
    Location:306 → 487
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  5. NM_001298471.1 → NP_001285400.1  Rho GTPase activating protein at 16F, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285400.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9UND9, X2JCF3
    Conserved Domains (1) summary
    cd00159
    Location:306 → 487
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q960F5 Q960F5
Q9VWY8 Q9VWY8
X2JCF3 X2JCF3

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