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Dtd2 D-tyrosyl-tRNA deacylase 2 [ Mus musculus (house mouse) ]

Gene ID: 328092, updated on 27-Nov-2024

Summary

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Official Symbol
Dtd2provided by MGI
Official Full Name
D-tyrosyl-tRNA deacylase 2provided by MGI
Primary source
MGI:MGI:1923485
See related
Ensembl:ENSMUSG00000020956 AllianceGenome:MGI:1923485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATD; 4930578F06Rik; 6530401N04Rik; B830049N13Rik
Summary
Enables Ala-tRNA(Thr) hydrolase activity and D-tyrosyl-tRNA(Tyr) deacylase activity. Involved in aminoacyl-tRNA metabolism involved in translational fidelity. Predicted to be active in cytoplasm. Orthologous to human DTD2 (D-aminoacyl-tRNA deacylase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 2.9), liver E18 (RPKM 2.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dtd2 in Genome Data Viewer
Location:
12 22.11 cM; 12 C1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (52035089..52053290, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (51988306..52006507, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3051 Neighboring gene STARR-seq mESC enhancer starr_32114 Neighboring gene predicted gene, 34894 Neighboring gene HEAT repeat containing 5A Neighboring gene STARR-seq mESC enhancer starr_32115 Neighboring gene STARR-seq mESC enhancer starr_32116 Neighboring gene G protein-coupled receptor 33 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia. Kuncha SK, et al. Nat Commun, 2018 Feb 6. PMID 29410408, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Ala-tRNA(Thr) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Ala-tRNA(Thr) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-tyrosyl-tRNA(Tyr) deacylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aminoacyl-tRNA metabolism involved in translational fidelity ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-aminoacyl-tRNA deacylase 2
Names
L-alanyl-tRNA deacylase
animalia-specifc tRNA deacylase
animalia-specific tRNA deacylase
probable D-tyrosyl-tRNA(Tyr) deacylase 2
putative D-tyrosyl-tRNA deacylase 2
putative D-tyrosyl-tRNA(Tyr) deacylase 2
NP_001334333.1
NP_083821.1
XP_036013397.1
XP_036013398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347404.1 → NP_001334333.1  D-aminoacyl-tRNA deacylase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK016300, BY069987, BY423647
    Consensus CDS
    CCDS83962.1
    UniProtKB/Swiss-Prot
    Q8BHA3
    Related
    ENSMUSP00000082525.4, ENSMUST00000085404.10

  2. NM_029545.3 → NP_083821.1  D-aminoacyl-tRNA deacylase 2 isoform 2

    See identical proteins and their annotated locations for NP_083821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK042771, BY069987
    Consensus CDS
    CCDS25903.1
    UniProtKB/Swiss-Prot
    Q8BHA3, Q9D363, Q9D4Q5
    Related
    ENSMUSP00000021339.8, ENSMUST00000021339.8
    Conserved Domains (1) summary
    pfam02580
    Location:12 → 167
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    52035089..52053290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157504.1 → XP_036013397.1  D-aminoacyl-tRNA deacylase 2 isoform X1

    Conserved Domains (1) summary
    pfam02580
    Location:1 → 92
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

  2. XM_036157505.1 → XP_036013398.1  D-aminoacyl-tRNA deacylase 2 isoform X1

    Conserved Domains (1) summary
    pfam02580
    Location:1 → 92
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHA3.1 GenPept UniProtKB/Swiss-Prot:Q8BHA3

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