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Ggt-1 gamma-glutamyl transpeptidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32839, updated on 9-Dec-2024

Summary

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Official Symbol
Ggt-1provided by FlyBase
Official Full Name
gamma-glutamyl transpeptidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0030932
Locus tag
Dmel_CG6461
See related
AllianceGenome:FB:FBgn0030932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6461; Dmel\CG6461; GGT-1
Summary
Enables glutathione hydrolase activity. Involved in glutathione metabolic process and response to light stimulus. Located in extracellular space. Is expressed in adult head; embryonic proventriculus; and organism. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ggt-1 in Genome Data Viewer
Location:
17C1-17C1; 1-60 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18505883..18512521, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18399916..18406554, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 2 Neighboring gene Wnt oncogene analog 5 Neighboring gene uncharacterized protein Neighboring gene Histidyl-tRNA synthetase Neighboring gene Beadex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activatable Raman Probes Utilizing Enzyme-Induced Aggregate Formation for Selective Ex Vivo Imaging. Fujioka H, et al. J Am Chem Soc, 2023 Apr 26. PMID 37057960, Free PMC Article
  2. γ-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABAA receptors in Drosophila. Liu J, et al. J Neurochem, 2014 Aug. PMID 24702462
  3. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Yoshikawa S, et al. Nature, 2003 Apr 10. PMID 12660735
  4. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
  5. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-glutamyl transpeptidase
Names
CG6461-PA
CG6461-PB
Ggt-1-PA
Ggt-1-PB
gamma-glutamyl transferase
NP_001285408.1
NP_573303.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18505883..18512521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133075.3 → NP_573303.1  gamma-glutamyl transpeptidase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573303.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TL5, Q9VWT3
    Related
    FBpp0074393
    Conserved Domains (1) summary
    pfam01019
    Location:56 → 566
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. NM_001298479.1 → NP_001285408.1  gamma-glutamyl transpeptidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285408.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TL5, Q9VWT3
    Conserved Domains (1) summary
    pfam01019
    Location:56 → 566
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWT3 Q9VWT3

Gene LinkOut

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