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Rip11 Rab11 interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32850, updated on 4-Jan-2025

Summary

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Official Symbol
Rip11provided by FlyBase
Official Full Name
Rab11 interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0027335
Locus tag
Dmel_CG6606
See related
AllianceGenome:FB:FBgn0027335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6606; Dmel\CG6606; dRip11; l(1)G0003; l(1)G0070; l(1)G0092; l(1)G0205; l(1)G0297; l(1)G0434; rip11
Summary
Enables small GTPase binding activity. Involved in rhabdomere development. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in embryonic hypopharynx; larval muscle system; midline glial cell; midline primordium; and organism. Orthologous to human RAB11FIP1 (RAB11 family interacting protein 1); RAB11FIP2 (RAB11 family interacting protein 2); and RAB11FIP5 (RAB11 family interacting protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Rip11 in Genome Data Viewer
Location:
17C6-17C7; 1-60 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18635642..18647648, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18529675..18541681, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44705 Neighboring gene wengen Neighboring gene Nucleoporin 35kDa Neighboring gene Houki Neighboring gene Inhibitor of growth family, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development. Calero-Cuenca FJ, et al. Small GTPases, 2018 Jul 4. PMID 27687567, Free PMC Article
  2. In vitro and in vivo characterization of the Rab11-GAP activity of Drosophila Evi5. Laflamme C, et al. Methods Mol Biol, 2015. PMID 25800843
  3. Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. Miettinen TP, et al. Cell Rep, 2015 Dec 22. PMID 26686643, Free PMC Article
  4. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. Guichard A, et al. PLoS Pathog, 2017 Sep. PMID 28945820, Free PMC Article
  5. The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11. Ji HH, et al. Biochem J, 2015 Jul 1. PMID 25940004

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Delivers morphogenic secretory traffic along polarized actin filaments of the subcortical terminal web to the exocytic plasma membrane target, the rhabdomere base.
    Title: Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rab11 interacting protein
Names
CG6606-PA
CG6606-PB
CG6606-PC
CG6606-PD
CG6606-PE
Rip11-PA
Rip11-PB
Rip11-PC
Rip11-PD
Rip11-PE
lethal (1) G0003

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18635642..18647648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169320.2 → NP_001162791.1  Rab11 interacting protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162791.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q494I2
    Conserved Domains (2) summary
    cd08682
    Location:7 → 130
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:352 → 399
    RBD-FIP; FIP domain

  2. NM_001298482.1 → NP_001285411.1  Rab11 interacting protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JEA7
    Conserved Domains (2) summary
    cd08682
    Location:7 → 130
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:352 → 399
    RBD-FIP; FIP domain

  3. NM_001298484.1 → NP_001285413.1  Rab11 interacting protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285413.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JFP6
    Conserved Domains (2) summary
    cd08682
    Location:7 → 130
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:758 → 805
    RBD-FIP; FIP domain

  4. NM_001298483.1 → NP_001285412.1  Rab11 interacting protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JL40
    Conserved Domains (2) summary
    cd08682
    Location:7 → 130
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:758 → 805
    RBD-FIP; FIP domain

  5. NM_133085.4 → NP_573313.2  Rab11 interacting protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573313.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWS3
    Related
    FBpp0074387
    Conserved Domains (2) summary
    cd08682
    Location:7 → 130
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:758 → 805
    RBD-FIP; FIP domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q494I2 Q494I2
Q95SD9 Q95SD9
Q9VWS3 Q9VWS3
X2JEA7 X2JEA7
X2JFP6 X2JFP6
X2JL40 X2JL40

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