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Ing3 Inhibitor of growth family, member 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32853, updated on 9-Dec-2024

Summary

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Official Symbol
Ing3provided by FlyBase
Official Full Name
Inhibitor of growth family, member 3provided by FlyBase
Primary source
FLYBASE:FBgn0030945
Locus tag
Dmel_CG6632
See related
AllianceGenome:FB:FBgn0030945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6632; dIng3; dIng3~; Dmel\CG6632; ING3
Summary
Predicted to enable methylated histone binding activity. Involved in DNA repair-dependent chromatin remodeling. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ing3 in Genome Data Viewer
Location:
17C7-17C7; 1-60 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18650718..18653091, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18544751..18547124, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rab11 interacting protein Neighboring gene Nucleoporin 35kDa Neighboring gene Houki Neighboring gene uncharacterized protein Neighboring gene fused Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. Kanda H, et al. J Biol Chem, 2002 Aug 9. PMID 12084706
  2. Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. Duncan OF, et al. PLoS Genet, 2018 Jul. PMID 30059502, Free PMC Article
  3. Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression. Kusch T, et al. Proc Natl Acad Sci U S A, 2014 Apr 1. PMID 24639513, Free PMC Article
  4. In and out: histone variant exchange in chromatin. Jin J, et al. Trends Biochem Sci, 2005 Dec. PMID 16257529
  5. Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity. Bailetti AA, et al. Dis Model Mech, 2019 May 30. PMID 31072879, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of growth family, member 3
Names
CG6632-PA
Ing3-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18650718..18653091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133088.1 → NP_573316.1  inhibitor of growth family, member 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573316.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWS0
    Related
    FBpp0074385, FBtr0074614
    Conserved Domains (2) summary
    cd15585
    Location:630 → 674
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:3 → 103
    ING; Inhibitor of growth proteins N-terminal histone-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR26 Q8MR26
Q9VWS0 Q9VWS0

Gene LinkOut

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