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CG6873 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32861, updated on 4-Jan-2025

Summary

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Official Symbol
CG6873provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030951
Locus tag
Dmel_CG6873
See related
AllianceGenome:FB:FBgn0030951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
adf; Dmel\CG6873
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament fragmentation and actin filament severing. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG6873 in Genome Data Viewer
Location:
17D3-17D3; 1-60 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18739216..18739895, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18633249..18633928, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45512 Neighboring gene long non-coding RNA:CR45513 Neighboring gene uncharacterized protein Neighboring gene Cholecystokinin-like receptor at 17D3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SKAR is a specific target of S6 kinase 1 in cell growth control. Richardson CJ, et al. Curr Biol, 2004 Sep 7. PMID 15341740
  2. The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size. Deng S, et al. Dev Biol, 2021 Jan 1. PMID 32980309, Free PMC Article
  3. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
  4. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article
  5. RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. Dorer MS, et al. PLoS Pathog, 2006 Apr. PMID 16652170, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
Adf/cofilin-like
CG6873-PA
cofilin homologue

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18739216..18739895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133093.2 → NP_573321.1  uncharacterized protein Dmel_CG6873 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573321.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWR1
    Related
    FBpp0074378
    Conserved Domains (1) summary
    cd11286
    Location:3 → 142
    ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWR1 Q9VWR1

Gene LinkOut

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