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Vwa5b2 von Willebrand factor A domain containing 5B2 [ Mus musculus (house mouse) ]

Gene ID: 328643, updated on 27-Nov-2024

Summary

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Official Symbol
Vwa5b2provided by MGI
Official Full Name
von Willebrand factor A domain containing 5B2provided by MGI
Primary source
MGI:MGI:2681859
See related
Ensembl:ENSMUSG00000046613 AllianceGenome:MGI:2681859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm931; Gm1738; EG328644
Summary
Is expressed in nervous system; pancreas trunk epithelium; and sensory organ. Orthologous to human VWA5B2 (von Willebrand factor A domain containing 5B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 10.8), frontal lobe adult (RPKM 7.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Vwa5b2 in Genome Data Viewer
Location:
16 A3; 16 12.47 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20408174..20424128)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20589428..20605378)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family F member 3 Neighboring gene predicted gene, 20164 Neighboring gene predicted gene, 35685 Neighboring gene microRNA 1224 Neighboring gene STARR-positive B cell enhancer ABC_E10894 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene ALG3 alpha-1,3- mannosyltransferase Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC62438, MGC130431, MGC180294, MGC180377

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
von Willebrand factor A domain-containing protein 5B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144953.1 → NP_001138425.1  von Willebrand factor A domain-containing protein 5B2 isoform 1

    See identical proteins and their annotated locations for NP_001138425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087898, AK045595, AK141799, BE862588, BM950198, BP765893, CA751913
    Consensus CDS
    CCDS49792.1
    UniProtKB/Swiss-Prot
    Q2TB01, Q3UR50, Q80WS8, Q8BR57
    UniProtKB/TrEMBL
    E0CZ01
    Related
    ENSMUSP00000093911.5, ENSMUST00000096197.11
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 652
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:353 → 501
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_001384104.1 → NP_001371033.1  von Willebrand factor A domain-containing protein 5B2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (2) summary
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:354 → 501
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. NM_001384105.1 → NP_001371034.1  von Willebrand factor A domain-containing protein 5B2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087898
    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (2) summary
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:354 → 501
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. NM_182636.4 → NP_872574.2  von Willebrand factor A domain-containing protein 5B2 isoform 2

    See identical proteins and their annotated locations for NP_872574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternative 3' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087898
    Consensus CDS
    CCDS37288.1
    UniProtKB/Swiss-Prot
    Q3UR50
    Related
    ENSMUSP00000097652.4, ENSMUST00000100074.10
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 556
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:353 → 501
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20408174..20424128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249160.2 → XP_030105020.1  von Willebrand factor A domain-containing protein 5B2 isoform X3

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 653
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:354 → 501
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_030249158.2 → XP_030105018.1  von Willebrand factor A domain-containing protein 5B2 isoform X1

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 657
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:358 → 505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_030249163.2 → XP_030105023.1  von Willebrand factor A domain-containing protein 5B2 isoform X6

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (2) summary
    TIGR03788
    Location:28 → 642
    marine_srt_targ; marine proteobacterial sortase target protein
    cl00057
    Location:343 → 490
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_030249164.2 → XP_030105024.1  von Willebrand factor A domain-containing protein 5B2 isoform X7

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (2) summary
    TIGR03788
    Location:28 → 638
    marine_srt_targ; marine proteobacterial sortase target protein
    cl00057
    Location:339 → 486
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  5. XM_006522299.5 → XP_006522362.1  von Willebrand factor A domain-containing protein 5B2 isoform X4

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 657
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:358 → 505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  6. XM_006522295.5 → XP_006522358.1  von Willebrand factor A domain-containing protein 5B2 isoform X2

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 656
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:358 → 505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  7. XM_017317053.3 → XP_017172542.1  von Willebrand factor A domain-containing protein 5B2 isoform X5

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 656
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:358 → 505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  8. XM_030249157.2 → XP_030105017.1  von Willebrand factor A domain-containing protein 5B2 isoform X1

    UniProtKB/TrEMBL
    E0CZ01
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 657
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:358 → 505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  9. XM_030249159.2 → XP_030105019.1  von Willebrand factor A domain-containing protein 5B2 isoform X3

    UniProtKB/TrEMBL
    E0CZ01
    Related
    ENSMUSP00000123727.2, ENSMUST00000159780.2
    Conserved Domains (3) summary
    TIGR03788
    Location:36 → 653
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam13757
    Location:2 → 79
    VIT_2; Vault protein inter-alpha-trypsin domain
    cl00057
    Location:354 → 501
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RNA

  1. XR_004939197.1 RNA Sequence

  2. XR_001781838.3 RNA Sequence

  3. XR_001781839.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198629.1: Suppressed sequence

    Description
    NM_198629.1: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UR50.2 GenPept UniProtKB/Swiss-Prot:Q3UR50

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