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CG6891 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32865, updated on 4-Jan-2025

Summary

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Official Symbol
CG6891provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030955
Locus tag
Dmel_CG6891
See related
AllianceGenome:FB:FBgn0030955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cotl1; Dmel\CG6891
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be active in cortical actin cytoskeleton and site of polarized growth. Predicted to colocalize with actin filament. Is expressed in several structures, including adult head; larval muscle cell; larval muscle system; posterior endoderm; and posterior midgut primordium. Orthologous to human COTL1 (coactosin like F-actin binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6891 in Genome Data Viewer
Location:
17D4-17D5; 1-60 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18775228..18781345)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18669261..18675378)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cholecystokinin-like receptor at 17D3 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene S6 Kinase Like Neighboring gene Autophagy-related 101

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coactosin-like protein 1 regulates integrity and repair of model intestinal epithelial barriers via actin binding dependent and independent mechanisms. Lechuga S, et al. Front Cell Dev Biol, 2024. PMID 39040043, Free PMC Article
  2. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors. Pézeron G, et al. J Cell Sci, 2014 Nov 1. PMID 25217625, Free PMC Article
  3. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
  4. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Mastushita-Sakai T, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547833, Free PMC Article
  5. Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. Webb JL, et al. PLoS One, 2021. PMID 34379632, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6891-PA
CG6891-PB
CG6891-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18775228..18781345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133095.2 → NP_573323.1  uncharacterized protein Dmel_CG6891, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573323.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWQ7
    Related
    FBpp0074402
    Conserved Domains (1) summary
    cd11282
    Location:28 → 139
    ADF_coactosin_like; Coactosin-like members of the ADF homology domain family

  2. NM_001272760.1 → NP_001259689.1  uncharacterized protein Dmel_CG6891, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQX5
    Conserved Domains (1) summary
    cd11282
    Location:11 → 122
    ADF_coactosin_like; Coactosin-like members of the ADF homology domain family

  3. NM_167630.2 → NP_728196.1  uncharacterized protein Dmel_CG6891, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQX5
    Related
    FBpp0074403
    Conserved Domains (1) summary
    cd11282
    Location:11 → 122
    ADF_coactosin_like; Coactosin-like members of the ADF homology domain family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQX5 Q8IQX5
Q8MQZ6 Q8MQZ6
Q9VWQ7 Q9VWQ7

Gene LinkOut

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