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Lipo1 lipase, member O1 [ Mus musculus (house mouse) ]

Gene ID: 329055, updated on 4-Jan-2025

Summary

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Official Symbol
Lipo1provided by MGI
Official Full Name
lipase, member O1provided by MGI
Primary source
MGI:MGI:3647308
See related
Ensembl:ENSMUSG00000079342 AllianceGenome:MGI:3647308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5097; EG329055
Summary
Predicted to enable sterol ester esterase activity. Predicted to be involved in sterol metabolic process. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Lipo1 in Genome Data Viewer
Location:
19 C1; 19 29.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33753437..33764852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (33776037..33787452, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8980 Neighboring gene STARR-seq mESC enhancer starr_45979 Neighboring gene STARR-seq mESC enhancer starr_45980 Neighboring gene lipase, member O2 Neighboring gene STARR-seq mESC enhancer starr_45981 Neighboring gene STARR-seq mESC enhancer starr_45982 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45983 Neighboring gene STARR-seq mESC enhancer starr_45985 Neighboring gene predicted gene, 23095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo). Holmes RS, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2010 Sep. PMID 20598663, Free PMC Article
  2. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. Ozyildirim AM, et al. Invest Ophthalmol Vis Sci, 2005 May. PMID 15851553
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sterol ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipase, member O1
Names
lipase, member O3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323065.1 → NP_001309994.1  lipase, member O1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC098875, AC122846, CK616672, CK617048
    Consensus CDS
    CCDS89380.1
    UniProtKB/TrEMBL
    F6WYC8
    Related
    ENSMUSP00000118385.3, ENSMUST00000148137.9
    Conserved Domains (3) summary
    pfam00561
    Location:77 → 375
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:33 → 94
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:77 → 242
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    33753437..33764852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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