Ulp1 Ulp1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ulp1provided by FlyBase
Official Full Name: Ulp1provided by FlyBase
Primary source: FLYBASE:FBgn0027603
Locus tag: Dmel_CG12359
See related: AllianceGenome:FB:FBgn0027603
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH02751; CG12359; Dmel\CG12359; DmUlp1; ulp1
Summary: Enables deSUMOylase activity. Involved in several processes, including negative regulation of signal transduction; neuron projection morphogenesis; and protein destabilization. Located in cytoplasm and nuclear inner membrane. Part of nuclear pore. Is expressed in several structures, including germarium; germline cell; gonad; and larval central nervous system. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19202103..19208187, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19096136..19102220, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Ulp1 may prevent proteins from leaving the nucleus with SUMO still attached
Title: Drosophila Ulp1, a nuclear pore-associated SUMO protease, prevents accumulation of cytoplasmic SUMO conjugates.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables deSUMOylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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