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Muc18B Mucin 18B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32913, updated on 4-Jan-2025

Summary

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Official Symbol
Muc18Bprovided by FlyBase
Official Full Name
Mucin 18Bprovided by FlyBase
Primary source
FLYBASE:FBgn0031000
Locus tag
Dmel_CG7876
See related
AllianceGenome:FB:FBgn0031000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7876; Dmel\CG7876
Summary
Predicted to be an extracellular matrix structural constituent. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including embryonic/larval gut; embryonic/larval posterior spiracle; embryonic/larval salivary gland; epithelial tube; and gut section. Orthologous to human HCG22 (HLA complex group 22 (non-protein coding)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Muc18B in Genome Data Viewer
Location:
18B1-18B1; 1-62 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19215515..19216660)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19109548..19110693)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mucin related 18B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences. May C, et al. J Biol Chem, 2020 Aug 28. PMID 32669364, Free PMC Article
  2. Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race. Castillo DM, et al. BMC Evol Biol, 2011 Sep 14. PMID 21917173, Free PMC Article
  3. A potential role for Drosophila mucins in development and physiology. Syed ZA, et al. PLoS One, 2008 Aug 22. PMID 18725942, Free PMC Article
  4. Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations. Riedl CA, et al. Behav Genet, 2005 May. PMID 15864439
  5. p120 catenin is required for the stress response in Drosophila. Stefanatos RK, et al. PLoS One, 2013. PMID 24349561, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix structural constituent ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mucin 18B
Names
CG7876-PA
CG7876-PB
Muc18B-PA
Muc18B-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19215515..19216660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298502.1 → NP_001285431.1  mucin 18B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285431.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWK2
    Conserved Domains (2) summary
    pfam01607
    Location:26 → 72
    CBM_14; Chitin binding Peritrophin-A domain
    pfam05934
    Location:77 → 177
    MCLC; Mid-1-related chloride channel (MCLC)

  2. NM_133137.3 → NP_573365.1  mucin 18B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573365.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWK2
    Related
    FBpp0074444
    Conserved Domains (2) summary
    pfam01607
    Location:26 → 72
    CBM_14; Chitin binding Peritrophin-A domain
    pfam05934
    Location:77 → 177
    MCLC; Mid-1-related chloride channel (MCLC)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWK2 Q9VWK2

Gene LinkOut

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