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kek5 kekkon 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32930, updated on 4-Jan-2025

Summary

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Official Symbol
kek5provided by FlyBase
Official Full Name
kekkon 5provided by FlyBase
Primary source
FLYBASE:FBgn0031016
Locus tag
Dmel_CG12199
See related
AllianceGenome:FB:FBgn0031016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12199; CT10486; Dmel\CG12199; kek-5; Kek5
Summary
Involved in negative regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; gut section; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See kek5 in Genome Data Viewer
Location:
18C3-18C7; 1-62 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19353181..19471914)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19247214..19365947)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha7 Neighboring gene outsiders Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 15/16 Neighboring gene narya Neighboring gene mitochondrial ribosomal protein S14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
  2. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
  3. Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Alvarado D, et al. Genetics, 2004 May. PMID 15166146, Free PMC Article
  4. Kekkon5 is an extracellular regulator of BMP signaling. Evans TA, et al. Dev Biol, 2009 Feb 1. PMID 19013143
  5. Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. Ulian-Benitez S, et al. PLoS Genet, 2017 Aug. PMID 28846707, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
kekkon 5
Names
CG12199-PA
CG12199-PB
CG12199-PC
CG12199-PD
kek5-PA
kek5-PB
kek5-PC
kek5-PD
kekkon-like
kekkon5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19353181..19471914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258817.2 → NP_001245746.1  kekkon 5, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PM1, Q9VWI6
    Conserved Domains (6) summary
    cd00096
    Location:296 → 376
    Ig; Immunoglobulin domain
    smart00370
    Location:122 → 145
    LRR; Leucine-rich repeats, outliers
    smart00082
    Location:229 → 277
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:76 → 160
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:76 → 100
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99 → 159
    LRR_8; Leucine rich repeat

  2. NM_167648.3 → NP_728243.1  kekkon 5, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PM1, Q9VWI6
    Related
    FBpp0301162
    Conserved Domains (6) summary
    cd00096
    Location:296 → 376
    Ig; Immunoglobulin domain
    smart00370
    Location:122 → 145
    LRR; Leucine-rich repeats, outliers
    smart00082
    Location:229 → 277
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:76 → 160
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:76 → 100
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99 → 159
    LRR_8; Leucine rich repeat

  3. NM_167647.3 → NP_728242.1  kekkon 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PM1, Q9VWI6
    Related
    FBpp0074476
    Conserved Domains (6) summary
    cd00096
    Location:296 → 376
    Ig; Immunoglobulin domain
    smart00370
    Location:122 → 145
    LRR; Leucine-rich repeats, outliers
    smart00082
    Location:229 → 277
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:76 → 160
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:76 → 100
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99 → 159
    LRR_8; Leucine rich repeat

  4. NM_133154.5 → NP_573382.1  kekkon 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PM1, Q9VWI6
    Related
    FBpp0074477
    Conserved Domains (6) summary
    cd00096
    Location:296 → 376
    Ig; Immunoglobulin domain
    smart00370
    Location:122 → 145
    LRR; Leucine-rich repeats, outliers
    smart00082
    Location:229 → 277
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:76 → 160
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:76 → 100
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99 → 159
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86PM1 Q86PM1
Q9VWI6 Q9VWI6

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