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Naa15-16 N(alpha)-acetyltransferase 15/16 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32934, updated on 4-Jan-2025

Summary

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Official Symbol
Naa15-16provided by FlyBase
Official Full Name
N(alpha)-acetyltransferase 15/16provided by FlyBase
Primary source
FLYBASE:FBgn0031020
Locus tag
Dmel_CG12202
See related
AllianceGenome:FB:FBgn0031020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12202; Dmel\CG12202; dNaa15; dNat1; l(1)G0311; Naa15; NAA15-16; Naa15/16; Nat1; NAT1
Summary
Predicted to enable acetyltransferase activator activity. Part of NatA complex. Is expressed in adult head. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit) and NAA16 (N-alpha-acetyltransferase 16, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Naa15-16 in Genome Data Viewer
Location:
18C7-18C7; 1-62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19479984..19484643)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19374017..19378676)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene kekkon 5 Neighboring gene long non-coding RNA:CR43260 Neighboring gene uncharacterized protein Neighboring gene narya Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene pacman

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered. Grima DP, et al. Biol Cell, 2008 Dec. PMID 18547166
  2. Xrn1/Pacman affects apoptosis and regulates expression of hid and reaper. Waldron JA, et al. Biol Open, 2015 Apr 2. PMID 25836675, Free PMC Article
  3. Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila. Williams BC, et al. Curr Biol, 2003 Dec 2. PMID 14653991
  4. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
  5. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
N(alpha)-acetyltransferase 15/16
Names
CG12202-PA
CG12202-PB
N(alpha)-acetyltransferase 15
NAT1 ortholog
Naa15-16-PA
Naa15-16-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19479984..19484643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298510.1 → NP_001285439.1  N(alpha)-acetyltransferase 15/16, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285439.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWI2
    Conserved Domains (2) summary
    sd00006
    Location:83 → 109
    TPR; TPR repeat [structural motif]
    pfam12569
    Location:187 → 703
    NARP1; NMDA receptor-regulated protein 1

  2. NM_133156.2 → NP_573384.1  N(alpha)-acetyltransferase 15/16, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWI2
    Related
    FBpp0074480
    Conserved Domains (2) summary
    sd00006
    Location:83 → 109
    TPR; TPR repeat [structural motif]
    pfam12569
    Location:187 → 703
    NARP1; NMDA receptor-regulated protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWI2 Q9VWI2

Gene LinkOut

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