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CoRest CoRest [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32941, updated on 9-Dec-2024

Summary

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Official Symbol
CoRestprovided by FlyBase
Official Full Name
CoRestprovided by FlyBase
Primary source
FLYBASE:FBgn0261573
Locus tag
Dmel_CG42687
See related
AllianceGenome:FB:FBgn0261573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH01486; BcDNA:LD11215; CG32534; CG32535; CG33525; CG3878; CG42687; CoREST; CoRESTG; dCoREST; Dmel\CG42687; i169
Old locus tag
Dmel_CG32534; Dmel_CG33525
Summary
Enables chromatin binding activity and transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and positive regulation of DNA methylation-dependent heterochromatin formation. Located in nucleus. Part of transcription repressor complex. Is expressed in female germline cell; follicle cell; organism; and spermatozoon. Orthologous to human RCOR1 (REST corepressor 1); RCOR2 (REST corepressor 2); and RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CoRest in Genome Data Viewer
Location:
18C8-18C8; 1-62 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19521929..19530896)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19415962..19424929)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene 6-phosphofructo-2-kinase Neighboring gene Isocitrate dehydrogenase 3a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila. Jacobs J, et al. Science, 2023 Jul 14. PMID 37440660
  2. Distinct CoREST complexes act in a cell-type-specific manner. Mačinković I, et al. Nucleic Acids Res, 2019 Dec 16. PMID 31701127, Free PMC Article
  3. The CoREST complex regulates multiple histone modifications temporal-specifically in clock neurons. Lv P, et al. Open Biol, 2024 Jul. PMID 38981515, Free PMC Article
  4. Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues. Zhang S, et al. Int J Mol Sci, 2018 Apr 10. PMID 29642630, Free PMC Article
  5. CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. Domanitskaya E, et al. J Cell Sci, 2012 Jan 15. PMID 22331351, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
    Title: Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
  2. This study uncovers three distinct dCoREST complexes that function in a lineage-restricted fashion to repress specific sets of genes thereby maintaining cell-type-specific gene expression programmes.
    Title: Distinct CoREST complexes act in a cell-type-specific manner.
  3. The data indicate that CoREST acts as a positive modulator of the Notch pathway in the follicular epithelium as well as in wing tissue, and suggests a previously unidentified role for CoREST in the regulation of Notch signaling.
    Title: CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transposable element silencing by piRNA-mediated heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription repressor complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
CoRest
Names
CG42687-PA
CG42687-PC
CG42687-PD
CG42687-PE
CG42687-PF
CG42687-PG
CG42687-PH
CG42687-PI
CG42687-PJ
CG42687-PK
CoRest-PA
CoRest-PC
CoRest-PD
CoRest-PE
CoRest-PF
CoRest-PG
CoRest-PH
CoRest-PI
CoRest-PJ
CoRest-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19521929..19530896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014754.1 → NP_001014754.1  CoRest, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014754.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3PFE5
    Conserved Domains (3) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. NM_001258824.1 → NP_001245753.1  CoRest, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAG1
    Conserved Domains (4) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:540 → 582
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. NM_001201742.3 → NP_001188671.1  CoRest, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188671.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAG1
    Conserved Domains (4) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:540 → 582
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  4. NM_001014752.4 → NP_001014752.2  CoRest, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014752.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4S3, Q494F9, Q59E35, Q59E36, Q8MSX7, Q95TC9, Q9VWH3
    Conserved Domains (4) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:306 → 348
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  5. NM_001014753.3 → NP_001014753.1  CoRest, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014753.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q59E36
    Conserved Domains (4) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:304 → 346
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  6. NM_001258825.2 → NP_001245754.1  CoRest, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245754.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAG1
    Conserved Domains (4) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:540 → 582
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  7. NM_001014755.2 → NP_001014755.1  CoRest, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3PFE5
    Conserved Domains (3) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  8. NM_001014756.2 → NP_001014756.1  CoRest, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3PFE5
    Conserved Domains (3) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  9. NM_001272777.1 → NP_001259706.1  CoRest, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259706.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3PFE5, M9PJR2
    Conserved Domains (3) summary
    smart00717
    Location:179 → 225
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:92 → 144
    ELM2; ELM2 domain
    cl21498
    Location:180 → 224
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  10. NM_001258826.1 → NP_001245755.1  CoRest, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5SHV0, M9NHB6
    Conserved Domains (2) summary
    smart00717
    Location:52 → 97
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:52 → 94
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C7LAG1 C7LAG1
M9NHB6 M9NHB6
M9PJR2 M9PJR2
Q59E36.2 Q59E36

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