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e(y)3 enhancer of yellow 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32965, updated on 4-Jan-2025

Summary

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Official Symbol
e(y)3provided by FlyBase
Official Full Name
enhancer of yellow 3provided by FlyBase
Primary source
FLYBASE:FBgn0087008
Locus tag
Dmel_CG12238
See related
AllianceGenome:FB:FBgn0087008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12238; Dmel\CG12238; E(y)3; e(y)[3]; l(1)G0084; l(1)G0266; l(1)G0283; l(1)G0381; l(1)G0409; sayp; SAYP
Summary
Enables chromatin binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in chromatin remodeling; negative regulation of DNA-templated transcription; and positive regulation of DNA-templated transcription. Located in chromosome and nucleus. Part of brahma complex. Is expressed in several structures, including anterior endoderm anlage; central brain primordium; clypeo-labral primordium; embryonic/larval midgut primordium; and ganglia. Used to study Coffin-Siris syndrome. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See e(y)3 in Genome Data Viewer
Location:
18D8-18D11; 1-63 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19626548..19638369, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19520581..19532402, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 20 A Neighboring gene MAPK Phosphatase 4 Neighboring gene uncharacterized protein Neighboring gene Required for cell differentiation 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [SAYP--a novel regulator of metazoan development]. Kuz'mina IuL, et al. Genetika, 2010 Aug. PMID 20873199
  2. [Novel conservative domain of SAYP coactivator mediates TFIID and Brahma transcriptional complexes interaction]. Vorob'eva NE, et al. Mol Biol (Mosk), 2010 Sep-Oct. PMID 21090241
  3. [Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines]. Brechalov AV, et al. Biofizika, 2011 Sep-Oct. PMID 22117439
  4. [SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation]. Vorob'eva NE, et al. Genetika, 2012 Jan. PMID 22567850
  5. [Protein products of zeste, e(y)1 and e(y)3 genes can effect the insulation process]. Georgieva SG, et al. Dokl Akad Nauk, 1998 Jan. PMID 9551323

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
    Title: Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
  2. In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
    Title: SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
  3. SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex during development and have multiple common targets across the genome.
    Title: [SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].
  4. The transcription coactivators SAYP and ENY2 act in gene expression as cooperative nanoregulators,determining the molecular mechanisms of spatial and temporal coordination of the processes involved in the realization of genetic information.
    Title: [Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines].
  5. DHR3 and SAYP interact during development and have multiple common targets across the genome
    Title: SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation.
  6. Novel conservative domain of SAYP coactivator mediates TFIID and Brahma transcriptional complexes interaction
    Title: [Novel conservative domain of SAYP coactivator mediates TFIID and Brahma transcriptional complexes interaction].
  7. SAYP serves as a basis for assembling the BTFly nuclear supercomplex consising of the Brahma and TFIID coactivators. BTFly may play an important role in ontogenesis.
    Title: [SAYP--a novel regulator of metazoan development].
  8. The existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, is shown.
    Title: Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex.
  9. SAYP is a signature subunit that plays a major role in the functional specificity of the PBAP holoenzyme.
    Title: The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complex.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of brahma complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
enhancer of yellow 3
Names
CG12238-PA
CG12238-PB
CG12238-PC
CG12238-PD
CG12238-PE
SAYP
e(y)3-PA
e(y)3-PB
e(y)3-PC
e(y)3-PD
e(y)3-PE
lethal (1) G0084
supporter of activation of yellow protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19626548..19638369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272789.1 → NP_001259718.1  enhancer of yellow 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C7LAD9, Q7JW70, Q9VWF2
    UniProtKB/TrEMBL
    M9PHL0
    Conserved Domains (3) summary
    sd00025
    Location:1694 → 1719
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15529
    Location:1750 → 1793
    PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins
    cl22851
    Location:1694 → 1748
    PHD_SF; PHD finger superfamily

  2. NM_001272792.1 → NP_001259721.1  enhancer of yellow 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259721.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C7LAD9, Q7JW70, Q9VWF2
    UniProtKB/TrEMBL
    M9PHL0
    Conserved Domains (3) summary
    sd00025
    Location:1694 → 1719
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15529
    Location:1750 → 1793
    PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins
    cl22851
    Location:1694 → 1748
    PHD_SF; PHD finger superfamily

  3. NM_134490.3 → NP_608334.3  enhancer of yellow 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608334.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C7LAD9, Q7JW70, Q9VWF2
    UniProtKB/TrEMBL
    M9PHL0
    Related
    FBpp0074531
    Conserved Domains (3) summary
    sd00025
    Location:1694 → 1719
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15529
    Location:1750 → 1793
    PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins
    cl22851
    Location:1694 → 1748
    PHD_SF; PHD finger superfamily

  4. NM_001272790.1 → NP_001259719.1  enhancer of yellow 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI16
    Conserved Domains (3) summary
    sd00025
    Location:1700 → 1725
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15529
    Location:1756 → 1799
    PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins
    cl22851
    Location:1700 → 1754
    PHD_SF; PHD finger superfamily

  5. NM_001272791.1 → NP_001259720.1  enhancer of yellow 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259720.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHZ0
    Conserved Domains (3) summary
    sd00025
    Location:1699 → 1724
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15529
    Location:1755 → 1798
    PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins
    cl22851
    Location:1699 → 1753
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHL0 M9PHL0
M9PHZ0 M9PHZ0
M9PI16 M9PI16
Q9VWF2.3 Q9VWF2

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