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Sec61gamma Sec61 gamma subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32968, updated on 9-Dec-2024

Summary

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Official Symbol
Sec61gammaprovided by FlyBase
Official Full Name
Sec61 gamma subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0031049
Locus tag
Dmel_CG14214
See related
AllianceGenome:FB:FBgn0031049
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14214; Dmel\CG14214; Sec61
Summary
Predicted to enable protein transmembrane transporter activity. Involved in negative regulation of autophagy. Predicted to be located in membrane. Predicted to be part of Sec61 translocon complex and Ssh1 translocon complex. Orthologous to human SEC61G (SEC61 translocon subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sec61gamma in Genome Data Viewer
Location:
18D11-18D12; 1-63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19643327..19644518)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19537360..19538551)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Required for cell differentiation 1 Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 10 Neighboring gene Ranbp21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Lu B, et al. Nat Neurosci, 2013 May. PMID 23525043
  2. Multiple classes of MSL binding sites target dosage compensation to the X chromosome of Drosophila. Oh H, et al. Curr Biol, 2004 Mar 23. PMID 15043812
  3. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Zhang SL, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16751269, Free PMC Article
  4. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
  5. EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila. Sekiya M, et al. Dev Cell, 2017 Jun 19. PMID 28633019, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Ssh1 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sec61 gamma subunit
Names
CG14214-PA
CG14214-PB
CG14214-PC
Sec61gamma-PA
Sec61gamma-PB
Sec61gamma-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19643327..19644518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298521.1 → NP_001285450.1  Sec61 gamma subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285450.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VWE9
    UniProtKB/TrEMBL
    X2JCL6
    Conserved Domains (1) summary
    cl00481
    Location:12 → 68
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

  2. NM_134493.3 → NP_608337.1  Sec61 gamma subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608337.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VWE9
    UniProtKB/TrEMBL
    X2JCL6
    Related
    FBpp0074514
    Conserved Domains (1) summary
    cl00481
    Location:12 → 68
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

  3. NM_001298522.1 → NP_001285451.1  Sec61 gamma subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VWE9
    UniProtKB/TrEMBL
    X2JCL6
    Conserved Domains (1) summary
    cl00481
    Location:12 → 68
    SecE; SecE/Sec61-gamma subunits of protein translocation complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWE9.1 Q9VWE9
X2JCL6 X2JCL6

Gene LinkOut

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