U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

et eye transformer [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32975, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
etprovided by FlyBase
Official Full Name
eye transformerprovided by FlyBase
Primary source
FLYBASE:FBgn0031055
Locus tag
Dmel_CG14225
See related
AllianceGenome:FB:FBgn0031055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14225; Dmel\CG14225; Et; ET; lat; Lat; Latran
Summary
Enables STAT family protein binding activity; protein dimerization activity; and protein tyrosine kinase binding activity. Involved in defense response to bacterium and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in membrane. Is expressed in medullary zone of lymph gland primary lobe. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18D13-18D13; 1-63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19672312..19675891, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19566345..19569924, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44512 Neighboring gene Ssu72 CTD phosphatase Neighboring gene Zwischenferment Neighboring gene domeless Neighboring gene Ubiquilin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a putative invertebrate helical cytokine similar to the ciliary neurotrophic factor/leukemia inhibitory factor family by PSI-BLAST-based approach. Cheng G, et al. J Interferon Cytokine Res, 2009 Aug. PMID 19514841
  2. JAK/STAT signaling is involved in air sac primordium development of Drosophila melanogaster. Powers N, et al. FEBS Lett, 2019 Apr. PMID 30854626
  3. Fat- and sugar-induced signals regulate sweet and fat taste perception in Drosophila. Zhao Y, et al. Cell Rep, 2023 Nov 28. PMID 37934669, Free PMC Article
  4. Rel governs loser elimination during stem cell competition in the Drosophila testis. Hof-Michel S, et al. Eur J Cell Biol, 2024 Mar. PMID 37995529
  5. Tools and methods for studying the Drosophila JAK/STAT pathway. Chen Q, et al. Methods, 2014 Jun 15. PMID 24685392

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Et/Lat is trafficked through the endocytic machinery for lysosomal degradation but at a much slower rate than Dome.
    Title: Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.
  2. We show that a short type I cytokine-related receptor CG14225/Latran is required for switching off JAK/STAT signalling in prohemocytes.
    Title: A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response.
  3. The gene CG14225 encoded the protein Eye Transformer and was found to negatively regulate the JAK/STAT signal pathway.
    Title: Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: c19674072-19673713 mobile_element_type = transposon:INE-1{}5633

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables STAT family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
eye transformer
Names
CG14225-PB
CG14225-PC
Eye transformer
et-PB
et-PC
latran

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19672312..19675891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258832.1 → NP_001245761.1  eye transformer, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245761.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE35

  2. NM_134499.2 → NP_608343.2  eye transformer, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608343.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVI7, Q9VWE1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NE35 M9NE35
Q9VWE1 Q9VWE1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools