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SkpC SKP1-related C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32996, updated on 9-Dec-2024

Summary

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Official Symbol
SkpCprovided by FlyBase
Official Full Name
SKP1-related Cprovided by FlyBase
Primary source
FLYBASE:FBgn0026175
Locus tag
Dmel_CG11941
See related
AllianceGenome:FB:FBgn0026175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11941; Dmel\CG11941; dskpC; Skp; skpC
Summary
Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SkpC in Genome Data Viewer
Location:
18F2-18F2; 1-64 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19816072..19816700)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19710105..19710733)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44885 Neighboring gene SKP1-related D Neighboring gene SKP1-related E Neighboring gene pico

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. Murphy TD. J Cell Sci, 2003 Jun 1. PMID 12730292
  2. RNA degradation is required for the germ-cell to maternal transition in Drosophila. Blatt P, et al. Curr Biol, 2021 Jul 26. PMID 33989522, Free PMC Article
  3. Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. Roberts DM, et al. PLoS One, 2012. PMID 22359584, Free PMC Article
  4. The E3 ligase Poe promotes Pericentrin degradation. Galletta BJ, et al. Mol Biol Cell, 2023 Aug 1. PMID 37342879, Free PMC Article
  5. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SKP1-related C
Names
CG11941-PA
SkpC-PA
skpC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19816072..19816700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134514.2 → NP_608358.1  SKP1-related C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608358.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHQ2, Q9VWC4
    Related
    FBpp0074566
    Conserved Domains (2) summary
    smart00512
    Location:6 → 114
    Skp1; Found in Skp1 protein family
    pfam01466
    Location:88 → 146
    Skp1; Skp1 family, dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWC4 Q9VWC4

Gene LinkOut

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