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THADA THADA [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33001, updated on 4-Jan-2025

Summary

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Official Symbol
THADAprovided by FlyBase
Official Full Name
THADAprovided by FlyBase
Primary source
FLYBASE:FBgn0031077
Locus tag
Dmel_CG15618
See related
AllianceGenome:FB:FBgn0031077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15618; Dmel\CG15618
Summary
Enables calcium channel inhibitor activity. Involved in adaptive thermogenesis and negative regulation of endoplasmic reticulum calcium ion concentration. Is active in cytoplasmic side of endoplasmic reticulum membrane. Is expressed in spermatozoon. Used to study obesity. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See THADA in Genome Data Viewer
Location:
18F4-18F4; 1-64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19859743..19865524, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19753776..19759557, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pico Neighboring gene Nucleoporin 205kD Neighboring gene Histone gene-specific Epigenetic Repressor in late S phase Neighboring gene amnesiac Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. THADA Regulates the Organismal Balance between Energy Storage and Heat Production. Moraru A, et al. Dev Cell, 2017 Apr 10. PMID 28399403, Free PMC Article
  2. Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster. Nicol A, et al. PLoS One, 2024. PMID 39196987, Free PMC Article
  3. tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila. Angelova MT, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31943105, Free PMC Article
  4. Drosophila as a model to study obesity and metabolic disease. Musselman LP, et al. J Exp Biol, 2018 Mar 7. PMID 29514880
  5. Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with the In Vivo Rescue Effects Tested on a Drosophila melanogaster High-Sugar Diet Model. Neamtu AA, et al. Antioxidants (Basel), 2020 Oct 30. PMID 33143302, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA nucleoside ribose methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic side of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
THADA
Names
CG15618-PB
CG15618-PC
THADA-PB
THADA-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19859743..19865524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134517.3 → NP_608361.3  THADA, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608361.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MQL6, Q9VWB9
    Conserved Domains (1) summary
    pfam10350
    Location:863 → 1112
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  2. NM_001258841.1 → NP_001245770.1  THADA, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245770.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFG3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NFG3 M9NFG3
Q9VWB9.3 Q9VWB9

Gene LinkOut

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