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Phf7 PHD finger protein 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33015, updated on 4-Jan-2025

Summary

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Official Symbol
Phf7provided by FlyBase
Official Full Name
PHD finger protein 7provided by FlyBase
Primary source
FLYBASE:FBgn0031091
Locus tag
Dmel_CG9576
See related
AllianceGenome:FB:FBgn0031091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9576; Dmel\CG9576; dPhf7; phf7; PHF7
Summary
Enables histone binding activity. Involved in male germ-line cyst formation; male germ-line sex determination; and positive regulation of gene expression. Located in male germ cell nucleus and polytene chromosome. Is expressed in several structures, including cuboidal/columnar epithelium; gonad; male germline cell; and male germline cyst. Orthologous to human PHF7 (PHD finger protein 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Phf7 in Genome Data Viewer
Location:
19B3-19C1; 1-64 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20160355..20165830, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20054388..20059863, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene asperous Neighboring gene Rab35 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Annexin B10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis. Wang XR, et al. Proc Biol Sci, 2017 May 31. PMID 28539513, Free PMC Article
  2. Genetic control of a sex-specific piRNA program. Chen P, et al. Curr Biol, 2023 May 8. PMID 37059098, Free PMC Article
  3. Control of a Novel Spermatocyte-Promoting Factor by the Male Germline Sex Determination Factor PHF7 of Drosophila melanogaster. Yang SY, et al. Genetics, 2017 Aug. PMID 28588035, Free PMC Article
  4. Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila. Gonzalez LE, et al. Genetics, 2021 Aug 26. PMID 34142134, Free PMC Article
  5. An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline. Smolko AE, et al. Development, 2020 Sep 11. PMID 32816970, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein.
    Title: Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein.
  2. Germline masculinization by Phf7 in D. melanogaster requires its evolutionarily novel C-terminus and the HP1-family protein HP1D3csd.
    Title: Germline masculinization by Phf7 in D. melanogaster requires its evolutionarily novel C-terminus and the HP1-family protein HP1D3csd.
  3. An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline.
    Title: An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline.
  4. Phf7 depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors.
    Title: The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila.
  5. PHF7 controls spermatogenesis by regulating the expression patterns of important male germline genes, including PEEPL1.
    Title: Control of a Novel Spermatocyte-Promoting Factor by the Male Germline Sex Determination Factor PHF7 of Drosophila melanogaster.
  6. Finger Protein 7 (PHF7) is an important factor for male germline sexual identity in Drosophila. Expression of PHF7 7 promotes spermatogenesis in XX germ cells when they are present in a male soma.
    Title: Phf7 controls male sex determination in the Drosophila germline.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in male germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male germ-line sex determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in male germ-line sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PHD finger protein 7
Names
CG9576-PA
CG9576-PB
CG9576-PC
PHD finger protein 7 ortholog
Phf7-PA
Phf7-PB
Phf7-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20160355..20165830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272812.1 → NP_001259741.1  PHD finger protein 7, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259741.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960N0, Q9W5W9
    Conserved Domains (1) summary
    cd15669
    Location:5 → 116
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

  2. NM_134530.3 → NP_608374.1  PHD finger protein 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608374.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960N0, Q9W5W9
    Related
    FBpp0070026
    Conserved Domains (1) summary
    cd15669
    Location:5 → 116
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

  3. NM_001272811.1 → NP_001259740.1  PHD finger protein 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259740.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960N0, Q9W5W9
    Conserved Domains (1) summary
    cd15669
    Location:5 → 116
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W5W9 Q9W5W9

Gene LinkOut

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