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obst-A obstructor-A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33022, updated on 4-Jan-2025

Summary

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Official Symbol
obst-Aprovided by FlyBase
Official Full Name
obstructor-Aprovided by FlyBase
Primary source
FLYBASE:FBgn0031097
Locus tag
Dmel_CG17052
See related
AllianceGenome:FB:FBgn0031097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17052; Dmel\CG17052; obst; Obst-A; ObstA
Summary
Enables chitin binding activity. A structural constituent of chitin-based cuticle. Involved in larval chitin-based cuticle development; negative regulation of extracellular matrix disassembly; and regulation of tube size, open tracheal system. Located in chitin-based extracellular matrix. Is expressed in several structures, including embryonic epipharynx; embryonic/larval spiracle primordium; epithelium; gut section; and primary segmental tracheal branch primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See obst-A in Genome Data Viewer
Location:
19C1-19C1; 1-64 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20239855..20243209)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20110929..20114283)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene short wing Neighboring gene long non-coding RNA:CR45465 Neighboring gene Peritrophin A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of airway tube diameter and integrity by secreted chitin-binding proteins in Drosophila. Tiklová K, et al. PLoS One, 2013. PMID 23826295, Free PMC Article
  2. Obstructor A organizes matrix assembly at the apical cell surface to promote enzymatic cuticle maturation in Drosophila. Pesch YY, et al. J Biol Chem, 2015 Apr 17. PMID 25737451, Free PMC Article
  3. Obstructor-A is required for epithelial extracellular matrix dynamics, exoskeleton function, and tubulogenesis. Petkau G, et al. J Biol Chem, 2012 Jun 15. PMID 22544743, Free PMC Article
  4. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Dong B, et al. Curr Opin Genet Dev, 2015 Jun. PMID 25819978
  5. rebuff regulates apical luminal matrix to control tube size in Drosophila trachea. Chandran RR, et al. Biol Open, 2018 Sep 5. PMID 30185423, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Obstructor A organizes matrix assembly at the apical cell surface to promote enzymatic cuticle maturation in Drosophila.
    Title: Obstructor A organizes matrix assembly at the apical cell surface to promote enzymatic cuticle maturation in Drosophila.
  2. The evolutionary conservation suggests a common role of Obstructor-A and homologs in coordinating extracellular matrix protection in epithelial tissues of chitinous invertebrates.
    Title: Obstructor-A is required for epithelial extracellular matrix dynamics, exoskeleton function, and tubulogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chitin-based cuticle IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chitin-based extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
obstructor-A
Names
CG17052-PA
CG17052-PB
Obstructor-A
obst-A-PA
obst-A-PB
obstructor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20239855..20243209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134534.3 → NP_608378.2  obstructor-A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608378.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VR79
    Related
    FBpp0077026
    Conserved Domains (1) summary
    pfam01607
    Location:180 → 225
    CBM_14; Chitin binding Peritrophin-A domain

  2. NM_001258849.2 → NP_001245778.1  obstructor-A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VR79
    Conserved Domains (1) summary
    pfam01607
    Location:180 → 225
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VR79 Q9VR79

Gene LinkOut

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