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Inx7 Innexin 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33027, updated on 4-Jan-2025

Summary

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Official Symbol
Inx7provided by FlyBase
Official Full Name
Innexin 7provided by FlyBase
Primary source
FLYBASE:FBgn0027106
Locus tag
Dmel_CG2977
See related
AllianceGenome:FB:FBgn0027106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2977; CG32731; D-inx-7; Dm-inx7; Dmel\CG2977; FBpp0070994; inx-7; inx7; prp7
Summary
Predicted to enable gap junction channel activity. Involved in medium-term memory. Located in cytoplasm; gap junction; and nucleus. Is expressed in adult brain; adult head; embryonic midgut constriction; embryonic/larval midgut; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Inx7 in Genome Data Viewer
Location:
6E4-6E4; 1-18 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6991612..6993612, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6885645..6903902, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene optic ganglion reduced Neighboring gene long non-coding RNA:CR44084 Neighboring gene boudin Neighboring gene long non-coding RNA:CR43837 Neighboring gene Innexin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila has several genes for gap junction proteins. Curtin KD, et al. Gene, 1999 May 31. PMID 10352230
  2. Gap junction proteins are not interchangeable in development of neural function in the Drosophila visual system. Curtin KD, et al. J Cell Sci, 2002 Sep 1. PMID 12154069
  3. Innexin-Mediated Adhesion between Glia Is Required for Axon Ensheathment in the Peripheral Nervous System. Das M, et al. J Neurosci, 2023 Mar 29. PMID 36801823, Free PMC Article
  4. The gap junction protein Innexin3 is required for eye disc growth in Drosophila. Richard M, et al. Dev Biol, 2017 May 15. PMID 28390801
  5. Gap junctions in Drosophila: developmental expression of the entire innexin gene family. Stebbings LA, et al. Mech Dev, 2002 May. PMID 11960713

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plays an essential role in axon guidance and embryonic nervous system development.
    Title: The Drosophila innexin 7 gap junction protein is required for development of the embryonic nervous system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intercellular transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in gap junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gap junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
innexin 7
Names
CG2977-PA
Inx7-PA
innexin7
pas related protein 7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6991612..6993612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176699.3 → NP_788872.1  innexin 7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788872.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP24, Q961J1, Q9V3W6
    Related
    FBpp0070994
    Conserved Domains (1) summary
    pfam00876
    Location:22 → 374
    Innexin; Innexin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3W6.1 Q9V3W6

Gene LinkOut

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