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Mdfic2 MyoD family inhibitor domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 330390, updated on 27-Nov-2024

Summary

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Official Symbol
Mdfic2provided by MGI
Official Full Name
MyoD family inhibitor domain containing 2provided by MGI
Primary source
MGI:MGI:2685611
See related
Ensembl:ENSMUSG00000090667 AllianceGenome:MGI:2685611
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm765
Summary
Predicted to be involved in negative regulation of DNA-templated transcription; regulation of JNK cascade; and regulation of Wnt signaling pathway. Predicted to be active in nucleus. Orthologous to human MDFIC2 (MyoD family inhibitor domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Mdfic2 in Genome Data Viewer
Location:
6 D3; 6 45.67 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (98212665..98319715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (98238014..98342754, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene melanogenesis associated transcription factor Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16804 Neighboring gene STARR-seq mESC enhancer starr_16808 Neighboring gene predicted gene, 53321 Neighboring gene STARR-seq mESC enhancer starr_16809 Neighboring gene predicted gene, 53320 Neighboring gene VISTA enhancer mm60 Neighboring gene predicted gene, 32592 Neighboring gene predicted gene, 32535 Neighboring gene Rho GDP dissociation inhibitor (GDI) alpha pseudogene Neighboring gene STARR-seq mESC enhancer starr_16810 Neighboring gene STARR-seq mESC enhancer starr_16811 Neighboring gene predicted gene, 32646 Neighboring gene STARR-seq mESC enhancer starr_16812 Neighboring gene predicted gene, 32705

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myoD family inhibitor domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128092.1 → NP_001121564.1  myoD family inhibitor domain-containing protein 2

    See identical proteins and their annotated locations for NP_001121564.1

    Status: PROVISIONAL

    Source sequence(s)
    BC147266
    Consensus CDS
    CCDS51863.1
    UniProtKB/TrEMBL
    B2RVL9
    Related
    ENSMUSP00000127120.2, ENSMUST00000164491.3
    Conserved Domains (1) summary
    pfam15316
    Location:25 → 189
    MDFI; MyoD family inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    98212665..98319715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166250.1 → XP_036022143.1  myoD family inhibitor domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15316
    Location:52 → 211
    MDFI; MyoD family inhibitor
Nucleotide Protein
Heading Accession and Version

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