cactin cactin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cactinprovided by FlyBase
Official Full Name: cactinprovided by FlyBase
Primary source: FLYBASE:FBgn0031114
Locus tag: Dmel_CG1676
See related: AllianceGenome:FB:FBgn0031114
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cactin; CG1676; Dmel\CG1676
Summary: Enables lncRNA binding activity. Involved in several processes, including mRNA splicing, via spliceosome; positive regulation of Toll signaling pathway; and positive regulation of antimicrobial humoral response. Part of catalytic step 2 spliceosome. Is expressed in organism. Orthologous to human CACTIN (cactin, spliceosome C complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20424069..20426402)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20295096..20297429)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila.
Title: Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila.
Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila.
Title: Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila.
Border cell polarity and collective migration require the spliceosome component Cactin.
Title: Border cell polarity and collective migration require the spliceosome component Cactin.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA cis splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain