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GstT3 Glutathione S transferase T3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33047, updated on 9-Dec-2024

Summary

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Official Symbol
GstT3provided by FlyBase
Official Full Name
Glutathione S transferase T3provided by FlyBase
Primary source
FLYBASE:FBgn0031117
Locus tag
Dmel_CG1702
See related
AllianceGenome:FB:FBgn0031117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg1702; CG1702; Dmel\CG1702; DmGSTT3a; DmGSTT3b; gstt3; GSTT3; GSTT3a; GSTT3b
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in adult midgut progenitor cell; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See GstT3 in Genome Data Viewer
Location:
19D1-19D1; 1-64 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20467455..20469796)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20338482..20340823)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene trabuco Neighboring gene Rho GTPase activating protein at 19D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Callebaut I, et al. Trends Biochem Sci, 2001 Feb. PMID 11166556
  2. Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila. Lv M, et al. Nucleic Acids Res, 2019 Apr 8. PMID 30649456, Free PMC Article
  3. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article
  4. Bowman-Birk inhibitor affects pathways associated with energy metabolism in Drosophila melanogaster. Li HM, et al. Insect Mol Biol, 2010 Jun 1. PMID 20113373
  5. Coordinated regulation of heterochromatic genes in Drosophila melanogaster males. Deng X, et al. Genetics, 2009 Jun. PMID 19307603, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S transferase T3
Names
CG1702-PA
CG1702-PB
CG1702-PC
GstT3-PA
GstT3-PB
GstT3-PC
NP_001162808.1
NP_001285495.1
NP_728347.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20467455..20469796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298566.1 → NP_001285495.1  glutathione S transferase T3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285495.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZE4, Q9VRA4
    Conserved Domains (3) summary
    cd03183
    Location:95 → 219
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:7 → 203
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:5 → 81
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

  2. NM_001169337.2 → NP_001162808.1  glutathione S transferase T3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162808.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DMK8, E1JJS1
    Conserved Domains (3) summary
    cd03183
    Location:135 → 259
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:47 → 243
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:45 → 121
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

  3. NM_167706.3 → NP_728347.1  glutathione S transferase T3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728347.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZE4, Q9VRA4
    Related
    FBpp0077002
    Conserved Domains (3) summary
    cd03183
    Location:95 → 219
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:7 → 203
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03050
    Location:5 → 81
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJS1 E1JJS1
Q8SZE4 Q8SZE4
Q9VRA4 Q9VRA4

Gene LinkOut

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