tilB touch insensitive larva B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tilBprovided by FlyBase
Official Full Name: touch insensitive larva Bprovided by FlyBase
Primary source: FLYBASE:FBgn0014395
Locus tag: Dmel_CG14620
See related: AllianceGenome:FB:FBgn0014395
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14620; Dmel\CG14620; TilB
Summary: Involved in several processes, including male courtship behavior, veined wing generated song production; sensory perception of sound; and temperature compensation of the circadian clock. Located in cytoplasm; dendrite; and motile cilium. Is expressed in several structures, including adult head; chordotonal neurons; chordotonal organ; male germline cell; and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 19. Orthologous to human DNAAF11 (dynein axonemal assembly factor 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (22449737..22451463)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (21851573..21853299)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The phenotypes and expression of tilB indicate function in cilia construction or maintenance.
Title: Hearing in Drosophila requires TilB, a conserved protein associated with ciliary motility.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium-dependent cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, veined wing generated song production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in temperature compensation of the circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed

Names: CG14620-PA; TilB; tilB-PA; touch insensitive larvaeB; touch-insensitive-larva-B

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The following sections contain reference sequences that belong to a specific genome build. Explain