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Cp110 Centriolar coiled coil protein 110kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33136, updated on 4-Jan-2025

Summary

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Official Symbol
Cp110provided by FlyBase
Official Full Name
Centriolar coiled coil protein 110kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0031191
Locus tag
Dmel_CG14617
See related
AllianceGenome:FB:FBgn0031191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14617; CG32501; CP110; DCP110; Dmel\CG14617
Summary
Involved in centriole elongation. Located in centriole. Is expressed in several structures, including antenna; antennal primordium; dorsal sensory complex primordium; embryonic head sensory system; and sensory nervous system primordium. Orthologous to human CCP110 (centriolar coiled-coil protein 110). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cp110 in Genome Data Viewer
Location:
20C1-20C1; 1-66 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22482082..22487458)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21883918..21889294)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin specific protease 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43493 Neighboring gene lethal (1) G0196 Neighboring gene long non-coding RNA:CR43962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Klp10A, a microtubule-depolymerizing kinesin-13, cooperates with CP110 to control Drosophila centriole length. Delgehyr N, et al. Curr Biol, 2012 Mar 20. PMID 22365849
  2. Cep104 is a component of the centriole distal tip complex that regulates centriole growth and contributes to Drosophila spermiogenesis. Ryniawec JM, et al. Curr Biol, 2023 Oct 9. PMID 37729913, Free PMC Article
  3. Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal end. Aydogan MG, et al. J Cell Sci, 2022 Jul 15. PMID 35707992, Free PMC Article
  4. Stepwise evolution of the centriole-assembly pathway. Carvalho-Santos Z, et al. J Cell Sci, 2010 May 1. PMID 20392737
  5. A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport. Safieddine A, et al. Nat Commun, 2021 Mar 1. PMID 33649340, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 22484705-22485067 mobile_element_type = transposon:INE-1{}3080
  • Loc: 22486238-22486730 mobile_element_type = transposon:INE-1{}3081

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in centriole elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome duplication IEA
Inferred from Electronic Annotation
more info
  
involved_in ciliary basal body organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centriolar coiled coil protein 110kDa
Names
CG14617-PA
CG14617-PB
CG14617-PC
CG14617-PD
CG14617-PE
CG14617-PF
CG14617-PG
CG14617-PH
Cp110-PA
Cp110-PB
Cp110-PC
Cp110-PD
Cp110-PE
Cp110-PF
Cp110-PG
Cp110-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    22482082..22487458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038768.2 → NP_001033857.1  centriolar coiled coil protein 110kDa, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PDW6, Q45EX2
    Conserved Domains (1) summary
    pfam16025
    Location:53 → 141
    CALM_bind; Calcium-dependent calmodulin binding

  2. NM_001298601.1 → NP_001285530.1  centriolar coiled coil protein 110kDa, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285530.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q45EX1, Q961V8, Q9VR58
    Conserved Domains (1) summary
    pfam16025
    Location:53 → 141
    CALM_bind; Calcium-dependent calmodulin binding

  3. NM_001038770.2 → NP_001033859.1  centriolar coiled coil protein 110kDa, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033859.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q45EX1, Q961V8, Q9VR58
    Conserved Domains (1) summary
    pfam16025
    Location:53 → 141
    CALM_bind; Calcium-dependent calmodulin binding

  4. NM_176775.2 → NP_788948.1  centriolar coiled coil protein 110kDa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788948.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q45EX1, Q961V8, Q9VR58
    Related
    FBpp0077045
    Conserved Domains (1) summary
    pfam16025
    Location:53 → 141
    CALM_bind; Calcium-dependent calmodulin binding

  5. NM_176776.3 → NP_788949.2  centriolar coiled coil protein 110kDa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788949.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PDW6, Q45EX2
    Conserved Domains (1) summary
    pfam16025
    Location:53 → 141
    CALM_bind; Calcium-dependent calmodulin binding

  6. NM_001298602.1 → NP_001285531.1  centriolar coiled coil protein 110kDa, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285531.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PDW6, Q45EX2
    Conserved Domains (1) summary
    pfam16025
    Location:53 → 141
    CALM_bind; Calcium-dependent calmodulin binding

  7. NM_001038769.2 → NP_001033858.1  centriolar coiled coil protein 110kDa, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033858.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q45EX1, Q961V8, Q9VR58
    Conserved Domains (1) summary
    pfam16025
    Location:53 → 141
    CALM_bind; Calcium-dependent calmodulin binding

  8. NM_001272847.2 → NP_001259776.1  centriolar coiled coil protein 110kDa, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259776.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAK4, M9PI43
    Conserved Domains (1) summary
    pfam16025
    Location:54 → 142
    CALM_bind; Calcium-dependent calmodulin binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI43 M9PI43
Q2PDW6 Q2PDW6
Q9VR58 Q9VR58

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