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Pus10 Pseudouridine synthase 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33178, updated on 9-Dec-2024

Summary

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Official Symbol
Pus10provided by FlyBase
Official Full Name
Pseudouridine synthase 10provided by FlyBase
Primary source
FLYBASE:FBgn0031227
Locus tag
Dmel_CG3709
See related
AllianceGenome:FB:FBgn0031227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0257455.7; CG3709; Dmel\CG3709
Summary
Predicted to enable tRNA pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Is expressed in organism and spermatozoon. Orthologous to human PUS10 (pseudouridine synthase 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Pus10 in Genome Data Viewer
Location:
21B3-21B3; 2-0.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (153539..155305, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (153539..155305, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 15 kDa subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome-wide analysis of pseudouridylation in Drosophila melanogaster. Song W, et al. G3 (Bethesda), 2023 Mar 9. PMID 36534986, Free PMC Article
  2. Nucleotide modifications in messenger RNA and their role in development and disease. Dezi V, et al. Biochem Soc Trans, 2016 Oct 15. PMID 27911721
  3. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. Doroszuk A, et al. BMC Genomics, 2012 May 4. PMID 22559237, Free PMC Article
  4. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
  5. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA pseudouridine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pseudouridine synthase 10
Names
CG3709-PA
Pus10-PA
NP_608500.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    153539..155305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134656.4 → NP_608500.1  pseudouridine synthase 10 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608500.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VPK7
    Related
    FBpp0077806
    Conserved Domains (2) summary
    PRK14554
    Location:253 → 489
    PRK14554; putative pseudouridylate synthase; Provisional
    cl00130
    Location:376 → 457
    PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPK7.2 Q9VPK7

Gene LinkOut

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