U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tbc1d15-17 TBC1 domain family member 15/17 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33184, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Tbc1d15-17provided by FlyBase
Official Full Name
TBC1 domain family member 15/17provided by FlyBase
Primary source
FLYBASE:FBgn0031233
Locus tag
Dmel_CG11490
See related
AllianceGenome:FB:FBgn0031233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11490; Dmel\CG11490
Summary
Enables small GTPase binding activity. Is expressed in embryonic/larval midgut and organism. Orthologous to human TBC1D15 (TBC1 domain family member 15) and TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tbc1d15-17 in Genome Data Viewer
Location:
21B4-21B4; 2-0.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (207179..210725)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (207179..210725)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene split ends Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene long non-coding RNA:CR44220 Neighboring gene long non-coding RNA:CR44222 Neighboring gene kismet

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Tbc1d15-17 regulates synaptic development at the Drosophila neuromuscular junction. Lee MJ, et al. Mol Cells, 2013 Aug. PMID 23812537, Free PMC Article
  2. Rab11 regulates cell-cell communication during collective cell movements. Ramel D, et al. Nat Cell Biol, 2013 Mar. PMID 23376974, Free PMC Article
  3. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
  4. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
  5. Endolysosomal trafficking controls yolk granule biogenesis in vitellogenic Drosophila oocytes. Yu Y, et al. PLoS Genet, 2024 Feb. PMID 38315726, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show novel role for Tbc1d15-17 and its potential substrate Rab7 in regulating synaptic development.
    Title: Tbc1d15-17 regulates synaptic development at the Drosophila neuromuscular junction.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
TBC1 domain family member 15/17
Names
CG11490-PA
CG11490-PB
CG11490-PC
TBC1 domain family, member 15/17 ortholog
Tbc1d15-17-PA
Tbc1d15-17-PB
Tbc1d15-17-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    207179..210725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272877.1 → NP_001259806.1  TBC1 domain family member 15/17, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPL5
    Conserved Domains (2) summary
    pfam12068
    Location:37 → 191
    DUF3548; Domain of unknown function (DUF3548)
    smart00164
    Location:369 → 598
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_001272878.1 → NP_001259807.1  TBC1 domain family member 15/17, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259807.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPL5
    Conserved Domains (2) summary
    pfam12068
    Location:37 → 191
    DUF3548; Domain of unknown function (DUF3548)
    smart00164
    Location:369 → 598
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. NM_134659.4 → NP_608503.1  TBC1 domain family member 15/17, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608503.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPL5
    Related
    FBpp0077784
    Conserved Domains (2) summary
    pfam12068
    Location:37 → 191
    DUF3548; Domain of unknown function (DUF3548)
    smart00164
    Location:369 → 598
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPL5 Q9VPL5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous